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Cancer chemoprevention with garlic and its constituents.
Advance metastasized cancers are generally incurable; hence an effort to prolong the process of carcinogenesis through chemoprevention has emerged consistent with this notion. In recent years, aExpand
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Resveratrol induces apoptosis involving mitochondrial pathways in mouse skin tumorigenesis.
Resveratrol, a plant constituent enriched in the skin of grapes, is one of the most promising agents for chemoprevention. In the present study, resveratrol-induced apoptosis in 7,Expand
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Assessment of impact of climate change on productivity of tea (Camellia sinensis L.) plantations in Sri Lanka
A study was undertaken to assess impact of climate change on productivity of tea lands in Sri Lanka. Findings of the study showed that tea cultivations at low and mid elevations are more vulnerableExpand
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Hepatoprotective effects of lupeol and mango pulp extract of carcinogen induced alteration in Swiss albino mice.
Lupeol, a triterpene present in mango and other fruits, is known to exhibit a number of pharmacological properties including antioxidant, antilithiatic, and antidiabetic effects. In the presentExpand
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Regulation of p53, nuclear factor kappaB and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin.
Bromelain is a pharmacologically active compound, present in stems and immature fruits of pineapples (Ananas cosmosus), which has been shown to have anti-edematous, anti-inflammatory, anti-thromboticExpand
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Regulation of signaling pathways involved in lupeol induced inhibition of proliferation and induction of apoptosis in human prostate cancer cells.
Prostate cancer (PCa) is the most frequently diagnosed noncutaneous cancer and the leading cause of cancer related deaths in men in the United States and many other Asian countries. Dietary factorsExpand
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c-Fos Is a Mediator of the c-Myc-induced Apoptotic Signaling in Serum-deprived Hepatoma Cells via the p38 Mitogen-activated Protein Kinase Pathway*
The proto-oncogene c-myc encodes a transcription factor that plays a pivotal role in cell proliferation, differentiation, and apoptosis. The signaling mechanism of c-Myc-induced apoptosis wasExpand
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Protective effects of lupeol and mango extract against androgen induced oxidative stress in Swiss albino mice.
AIM To investigate antioxidant potential of lupeol/mango pulp extract (MPE) in testosterone induced oxidative stress in prostate of male Swiss albino mice. METHODS Oral treatment of lupeol (1Expand
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Induction of Apoptosis by Lupeol and Mango Extract in Mouse Prostate and LNCaP Cells
Prostate cancer (PCA) is one of the most invasive malignancy and second leading cause of cancer related deaths in United States and some other countries. Long latency period makes PCA an idealExpand
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In vitro and in vivo modulation of testosterone mediated alterations in apoptosis related proteins by [6]-gingerol.
Ginger (Zingiber officinale, Zingiberaceae) has been widely used as a dietary spice, and as a traditional oriental medicine. The rhizome of ginger contains pungent vanillyl ketones, includingExpand
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