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Calcium Sequestering Ability of Mitochondria Modulates Influx of Calcium through Glutamate Receptor Channel
The excitotoxicity of glutamate is believed to be mediated by sustained increase in the cytosolic Ca2+ concentration. Mitochondria play a vital role in buffering the cytosolic calcium overload inExpand
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Melanocyte-keratinocyte interaction induces calcium signalling and melanin transfer to keratinocytes.
Physical contact between melanocytes and keratinocytes is a prerequisite for melanosome transfer to occur, but cellular signals induced during or after contact are not fully understood. Herein, it isExpand
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Glutamate-induced differential mitochondrial response in young and adult rats
Excitatory amino acid glutamate is involved in neurotransmission in the nervous system but it becomes a potent neurotoxin under variety of conditions. However, the molecular mechanism ofExpand
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NMDA and non-NMDA receptor-mediated differential Ca2+ load and greater vulnerability of motor neurons in spinal cord cultures
Glutamate receptor activated neuronal cell death has been implicated in the pathogenesis of motor neuron disease but the molecular mechanism responsible for neuronal dysfunction needs to beExpand
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Differential effects of tricyclic antidepressant drugs on membrane dynamics--a fluorescence spectroscopic study.
The effect of tricyclic antidepressant drugs amitriptyline, nortriptyline, imipramine and desipramine on synaptosomal membrane and lipid bilayer was studied using steady state and time dependentExpand
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AMPA induced Ca2+ influx in motor neurons occurs through voltage gated Ca2+ channel and Ca2+ permeable AMPA receptor
The rise in intracellular Ca(2+) mediated by AMPA subtype of glutamate receptors has been implicated in the pathogenesis of motor neuron disease, but the exact route of Ca(2+) entry into motorExpand
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Transient effects in quenching detected by harmonic-content frequency-domain fluorometry
Abstract Transient effects in the diffusional quenching of indole fluorescence by acrylamide were detected by frequency-domain fluorometry. The samples are excited with a repetitive train ofExpand
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Depalmitoylation preferentially downregulates AMPA induced Ca2+ signaling and neurotoxicity in motor neurons
Excessive activation of AMPA receptor has been implicated in motor neuron degeneration in amyotrophic lateral sclerosis (ALS). However, it is not clear why motor neurons are preferentially sensitiveExpand
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Biophysical Aspects of Ca2+ - Transport Sites in Skeletal and Cardiac Sarcoplasmic Reticulum (Ca2+ + Mg2+)-ATPase
Calcium is involved in a variety of cell functions, such as controlling cell division and growth, muscle contraction, hormone secretion, and in the excitation-contraction coupling mechanism (1).Expand
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Cerebrospinal fluid from amyotrophic lateral sclerosis patients preferentially elevates intracellular calcium and toxicity in motor neurons via AMPA/kainate receptor
Several lines of evidence in the literature purport the contribution of glutamate mediated excitotoxicity in the etiology of amyotrophic lateral sclerosis (ALS) but the cellular mechanismsExpand
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