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Phosphorylation and Calmodulin Binding of the Metabotropic Glutamate Receptor Subtype 5 (mGluR5) Are Antagonistic in Vitro *
It is reported that calmodulin interacts with the metabotropic glutamate receptor subtype 5 (mGluR5) in a Ca2+-dependent manner in vitro and antagonisms of the CaM binding and phosphorylation suggest the possibility that they regulate the receptor responses in vivo. Expand
STAT3 polymorphism predicts interferon-alfa response in patients with metastatic renal cell carcinoma.
  • N. Ito, M. Eto, +17 authors O. Ogawa
  • Medicine
  • Journal of clinical oncology : official journal…
  • 1 July 2007
The present study suggested that the STAT3 polymorphism is a useful diagnostic marker to predict the response to IFN-alpha therapy in patients with MRCC. Expand
Association of positional and functional candidate genes FGF1, FBN2, and LOX on 5q31 with intracranial aneurysm
No associations of FBN2 and LOX with IA were detected in the present study, and significant haplotype associations were not observed when haplotypes were constructed with the three, two, and four SNPs in FGF1 according to the linkage disequilibrium structure. Expand
Polymorphisms in the prostaglandin E2 receptor subtype 2 gene confer susceptibility to aspirin-intolerant asthma: a candidate gene approach.
A functional SNP of the EP2 gene associated with risk of AIA should decrease the transcription level, resulting in reduction of the PGE(2) braking mechanism of inflammation and involvement in the molecular mechanism underlying AIA. Expand
ADAM33 polymorphisms are associated with aspirin-intolerant asthma in the Japanese population
Sequence variations in ADAM33 are likely to correlate with susceptibility to AIA in the Japanese population. Expand
Evidence for natural selection in the HAVCR1 gene: high degree of amino-acid variability in the mucin domain of human HAVCR1 protein
Evidence that the effects of natural selection are largely restricted to the mucin domain of HAVCR1 suggests that this region may be of particular evolutionary and epidemiological interest. Expand
Local adaptation and population differentiation at the interleukin 13 and interleukin 4 loci
The strong LD observed in the IL-4 region may allow more efficient disease-association studies using this locus, and may account for some genetic variance underlying susceptibility to asthma and other allergic diseases. Expand