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NF-κ B Modulators from Valeriana officinalis
Valeriana officinalis (Valerianaceae) has been of great interest for its therapeutic uses for treating mild nervous tension and temporary sleeping problems. In traditional European medicine it has
A Comprehensive Review on Medicinal Plants as Antimicrobial Therapeutics: Potential Avenues of Biocompatible Drug Discovery
TLDR
This review focuses on the diverse effects and efficacy of herbal compounds in controlling the development of MDR in microbes and hopes to inspire research into unexplored plants with a view to identify novel antibiotics for global health benefits.
MicroRNAs in Cervical Cancer: Evidences for a miRNA Profile Deregulated by HPV and Its Impact on Radio-Resistance
TLDR
Recent evidence suggests an important level of interaction among E6/E7 viral proteins and cellular miRNA, and other noncoding RNAs among established infections and specific cellular miRNAs, to understand how those interactions could affect radio-therapeutic response in tumor cells.
F‐κB modulators from Valeriana officinalis
TLDR
The EtOAc extract of the underground parts of V. officinalis showed inhibitory activity against NF‐κB at 100 µg/mL in the IL‐6/Luc assay on HeLa cells and provided protection against excitotoxicity in primary brain cell cultures at micromolar concentrations.
Inhibitors of bacterial multidrug efflux pumps from the resin glycosides of Ipomoea murucoides.
TLDR
Stoloniferin I (8) enhanced norfloxacin activity 8-fold when incorporated at a concentration of 5 microg/mL, therefore, this type of amphipathic oligosaccharide could be developed further to provide more potent inhibitors of this multidrug efflux pump.
Reversal of multidrug resistance by morning glory resin glycosides in human breast cancer cells.
TLDR
Reversal of multidrug resistance (MDR) by thirty resin glycosides from the morning glory family (Convolvulaceae) was evaluated in vinblastine-resistant human breast carcinoma cells and results suggest that resin Glycosides represent potential efflux pump inhibitors for overcoming MDR in cancer therapy.
Physalins from Witheringia solanacea as modulators of the NF-kappaB cascade.
TLDR
It is suggested that the presence of a double bond and an epoxy ring between carbons 5 and 6 in compounds 1 and 2, respectively (which are not present in compound 3), are related to their anti-inflammatory activity.
A microRNA expression signature for clinical response in locally advanced cervical cancer.
TLDR
A set of miRNAs that can be used as molecular markers to predict the pathological response in locally advanced cervical cancer patients receiving radiation and chemotherapy treatment are identified.
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
TLDR
A set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes are presented.
Medicinal plants used in Mexican traditional medicine for the treatment of colorectal cancer.
TLDR
Medicinal plants are still a great source of novel chemical structures with antineoplastic potential as it is proven in this work.
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