• Publications
  • Influence
Pathogenesis of experimental Ebola virus infection in guinea pigs.
TLDR
The guinea pig model was used to investigate the pathologic events in EBO infection that lead to death, and the distribution of lesions, hematologic profiles, and increases in serum biochemical enzymes associated with EBO virus infection in guinea pigs was similar to reported findings in experimentally infected nonhuman primates and naturally infected humans. Expand
Lethal experimental infections of rhesus monkeys by aerosolized Ebola virus.
TLDR
Demonstration of fatal aerosol transmission of this virus in monkeys reinforces the importance of taking appropriate precautions to prevent its potential aerosol Transmission to humans. Expand
Evaluation of immune globulin and recombinant interferon-alpha2b for treatment of experimental Ebola virus infections.
TLDR
Effective treatment of Ebola infections may require a combination of drugs that inhibit viral replication in monocyte/macrophage-like cells while reversing the pathologic effects (e.g., coagulopathy) consequent to this replication. Expand
RICIN TOXIN
Apoptosis Induced In Vitro and In Vivo During Infection by Ebola and Marburg Viruses
TLDR
It is suggested that lymphopenia and lymphoid depletion associated with filoviral infections result from lymphocyte apoptosis induced by a number of factors that may include release of various chemical mediators from filovirus-infected or activated cells, damage to the fibroblastic reticular cell conduit system, and possibly stimulation by a viral protein. Expand
Lethal experimental infection of rhesus monkeys with Ebola-Zaire (Mayinga) virus by the oral and conjunctival route of exposure.
TLDR
Findings in this study experimentally confirm that Ebola virus can be effectively transmitted via the oral or conjunctival route of exposure in nonhuman primates. Expand
Dizocilpine (MK-801) arrests status epilepticus and prevents brain damage induced by soman
TLDR
The NMDA receptor may play a more critical role in the spread and maintenance, rather than the initiation of cholinergically-induced seizure activity, than in the spreading and maintenance of cholinesterase. Expand
Experimental infection of cynomolgus macaques with Ebola-Reston filoviruses from the 1989-1990 U.S. epizootic.
TLDR
This experiment demonstrated that EBO-R was lethal for macaques and was capable of initiating and sustaining the monkey epizootic and the potential for generating infectious aerosols seems prudent. Expand
Pathology of experimental inhalation anthrax in the rhesus monkey.
TLDR
In this study, compared with previous reports, meningitis and mesenteric lymph node hemorrhages were more common, whereas mediastinal and tracheobronchial lymph nodes hemorrhage were less common. Expand
Transmission of Ebola virus (Zaire strain) to uninfected control monkeys in a biocontainment laboratory
TLDR
Transmission of Ebola virus to two of three control rhesus monkeys that did not have direct contact with experimentally inoculated monkeys held in the same room is reported to suggest approaches to the study of routes of transmission to and among humans. Expand
...
1
2
3
4
...