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PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas
A recent report revealed that phosphoinositide-3-kinase, catalytic, alpha (PIK3CA) gene is somatically mutated in several types of human cancer, suggesting the mutated PIK3CA gene as an oncogene in… Expand
Mutational analysis of MED12 exon 2 in uterine leiomyoma and other common tumors
- E. M. Je, M. R. Kim, K. O. Min, N. J. Yoo, S. Lee
- International journal of cancer
- 15 September 2012
Recurrent somatic mutations in MED12 exon 2 have recently been reported in uterine leiomyomas. The recurrent nature of the mutations strongly suggests that the mutations may play important roles in… Expand
Echocardiographic epicardial fat thickness and coronary artery disease.
- Jin-Won Jeong, M. H. Jeong, +9 authors J. Park
- Circulation journal : official journal of the…
- 20 March 2007
BACKGROUND The association between epicardial fat and coronary artery disease has not been evaluated. The objective of the present study was to evaluate the relationship of echocardiographic… Expand
Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin
Nuclear factor erythroid‐related factor 2 (NRF2) encodes a transcription factor that induces expression of cytoprotective proteins upon oxidative stress and oncogenic NRF2 mutations have been found… Expand
Somatic Mutations of EGFR Gene in Squamous Cell Carcinoma of the Head and Neck
Purpose: Recently, the kinase domain mutations of epidermal growth factor receptor (EGFR) gene have been identified in non–small-cell lung cancer, and these mutations have been related to the… Expand
Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers
Missense somatic mutations in IDH1 gene affecting codon 132 have recently been reported in glioblastoma multiforme (GBM) and other gliomas. The recurrent nature of the IDH1 mutations in the same… Expand
Mutations of tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) and receptor 2 (TRAIL-R2) genes in metastatic breast cancers.
Several lines of evidence suggest that apoptosis dysregulation plays an important role in cancer metastasis. In this study, to explore the possibility that the mutations of death receptors are… Expand
Alterations of the DR5/TRAIL receptor 2 gene in non-small cell lung cancers.
Chromosome 8p21-22 is a frequent site of allelic deletions in many types of human tumors, including non-small cell lung cancer (NSCLC). Tumor necrosis factor-related apoptosis-inducing… Expand
Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas.
The MET protooncogene encodes a transmembrane tyrosine kinase identified as the receptor of a polypeptide known as hepatocyte growth factor/scatter factor. We performed PCR-based single-strand… Expand
Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias
Mounting evidence indicates that alterations of AKT signalling play important roles in cancer development. An earlier study discovered an oncogenic AKT1 gene mutation (AKT1 E17K) in breast,… Expand