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Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms are poorly understood. Using cell culture and mouse models, we show that obesity causes endoplasmic reticulumExpand
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XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response
ABSTRACT The mammalian unfolded protein response (UPR) protects the cell against the stress of misfolded proteins in the endoplasmic reticulum (ER). We have investigated here the contribution of theExpand
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XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation.
The differentiation of B cells into immunoglobulin-secreting plasma cells is controlled by two transcription factors, Blimp-1 and XBP1. By gene expression profiling, we defined a set of genes whoseExpand
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Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1
The transcription factor X-box binding protein 1 (XBP-1) is essential for the differentiation of plasma cells and the unfolded protein response (UPR). Here we show that UPR-induced splicing of XBP-1Expand
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Plasma cell differentiation requires the transcription factor XBP-1
Considerable progress has been made in identifying the transcription factors involved in the early specification of the B-lymphocyte lineage. However, little is known about factors that control theExpand
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Proteasome inhibitors disrupt the unfolded protein response in myeloma cells
Novel agents that target the proteasome, a proteolytic complex responsible for the degradation of ubiquitinated proteins, have demonstrated remarkable therapeutic efficacy in multiple myeloma, aExpand
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Proapoptotic BAX and BAK Modulate the Unfolded Protein Response by a Direct Interaction with IRE1α
Accumulation of misfolded protein in the endoplasmic reticulum (ER) triggers an adaptive stress response—termed the unfolded protein response (UPR)—mediated by the ER transmembrane protein kinase andExpand
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The transcription factor XBP-1 is essential for the development and survival of dendritic cells
Dendritic cells (DCs) play a critical role in the initiation, maintenance, and resolution of an immune response. DC survival is tightly controlled by extracellular stimuli such as cytokines andExpand
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The X‐box binding protein‐1 transcription factor is required for plasma cell differentiation and the unfolded protein response
Summary:  X‐box binding protein‐1 (XBP‐1) is a transcription factor essential for plasma cell differentiation. XBP‐1 transcripts are found at high levels in plasma cells from rheumatoid synovium andExpand
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XBP‐1 is required for biogenesis of cellular secretory machinery of exocrine glands
The secretory function of cells relies on the capacity of the endoplasmic reticulum (ER) to fold and modify nascent polypeptides and to synthesize phospholipids for the subsequent trafficking ofExpand
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