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Myelin Basic Protein-Specific TCR/HLA-DRB5*01:01 Transgenic Mice Support the Etiologic Role of DRB5*01:01 in Multiple Sclerosis
Genetic susceptibility to multiple sclerosis (MS) has been linked to the HLA-DR15 haplotype consisting of DRB1*15:01(DR2b) and DRB5*01:01(DR2a) alleles. Given almost complete linkage disequilibriumExpand
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Properties of protein kinase C isoforms (beta II, epsilon, and zeta) in a macrophage cell line (J774) and their roles in LPS-induced nitric oxide production.
Northern analysis of poly(A)+ RNA extracted from J774 cells (a mouse macrophage cell line) showed that this cell line constitutively expresses mRNAs specific for protein kinase C (PKC)-beta I, -betaExpand
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Inhibition of cell growth and tumorigenesis of human glioblastoma cells by a neutralizing antibody against human basic fibroblast growth factor
We report here that a neutralizing mouse monoclonal antibody against basic FGF inhibited both anchorage‐dependent and anchorage‐independent growth of U‐87MG and T98G human glioblastoma cells and HeLaExpand
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Differential regulation of lipopolysaccharide (LPS) activation pathways in mouse macrophages by LPS-binding proteins.
LPS binding to its receptor(s) on macrophages induces the synthesis of inflammatory mediators involved in septic shock. While the signaling mechanism(s) remains to be fully defined, the humanExpand
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Open Access
Inhibition of tyrosine protein kinase activity by synthetic isoflavones and flavones.
Sir: Tyrosine protein kinase is known to be associated with oncogene products of the retroviral src gene family^. This kinase activity is closely correlated with the ability of retroviruses toExpand
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Open Access
Mechanism of lipopolysaccharide-triggered junB activation in a mouse macrophage-like cell line (J774).
The effect of lipopolysaccharide (LPS) on the activation of junB in a mouse macrophage cell line (J774) was investigated. J774 cells responded to either phorbol 12-myristate 13-acetate (PMA) or LPSExpand
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Open Access
Tyrosine Phosphatase SHP-2 Is Involved in Regulation of Platelet-derived Growth Factor-induced Migration*
SHP-2 is a ubiquitously expressed Src homology-2-containing cytosolic tyrosine phosphatase that binds to and becomes tyrosine-phosphorylated by the activated platelet-derived growth factor receptor-βExpand
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Gene expression of fibroblast growth factor receptors in the tissues of human gliomas and meningiomas.
Northern blot analysis showed transcripts of two types of the fibroblast growth factor (FGF) receptor genes, flg and bek, in almost all the tissues samples of 18 human gliomas and 22 humanExpand
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Signal transduction by VEGF receptor-1 wild type and mutant proteins.
The role of the vascular endothelial growth factor receptor-1 (VEGFR-1) in endothelial cell function is unclear. We have previously identified four tyrosine phosphorylation sites in the C-terminalExpand
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Gap junctional intercellular communication and cell proliferation during rat liver carcinogenesis.
During multistage liver carcinogenesis, there is a sequential decrease in gap junctional intercellular communication (GJIC), associated with reduced expression of a major liver gap-junction proteinExpand
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Open Access