GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet.
- P. McClean, N. Irwin, R. Cassidy, J. Holst, V. Gault, P. Flatt
- Biology, MedicineAmerican Journal of Physiology. Endocrinology and…
- 1 December 2007
Data indicate that GIP receptor antagonism using (Pro(3))GIP provides an effective means of countering obesity and related diabetes induced by consumption of a high-fat, energy-rich diet.
Evidence for beneficial effects of compromised gastric inhibitory polypeptide action in obesity-related diabetes and possible therapeutic implications
Obese diabetic animals with compromised GIP action due to peptide-based GIP receptor antagonists, small molecular weight GIPceptor antagonists, vaccination against GIP, genetic knockout of GIP receptors or targeted K-cell destruction are protected against obesity and associated metabolic disturbances.
Islet distribution of Peptide YY and its regulatory role in primary mouse islets and immortalised rodent and human beta-cell function and survival
- D. Khan, S. Vasu, R. C. Moffett, N. Irwin, P. Flatt
- Biology, MedicineMolecular and Cellular Endocrinology
- 15 November 2016
Optimal bone mechanical and material properties require a functional glucagon-like peptide-1 receptor.
- G. Mabilleau, A. Mieczkowska, N. Irwin, P. Flatt, D. Chappard
- BiologyJournal of Endocrinology
- 1 October 2013
Bone is permanently remodeled by a complex network of local, hormonal, and neuronal factors that affect osteoclast and osteoblast biology. Among these factors, a role for gastrointestinal hormones…
Stable Incretin Mimetics Counter Rapid Deterioration of Bone Quality in Type 1 Diabetes Mellitus
- S. Mansur, A. Mieczkowska, G. Mabilleau
- Biology, MedicineJournal of Cellular Physiology
- 1 December 2015
Treatment of STZ‐diabetic mice with [D‐Ala2]GIP or liraglutide was capable of significantly preventing deterioration of the quality of the bone matrix, and further studies are required to further elucidate the molecular mechanisms involved and to validate whether these findings can be translated to human patients.
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