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Nodularin, a potent inhibitor of protein phosphatases 1 and 2A, is a new environmental carcinogen in male F344 rat liver.
TLDR
Nodularin itself is a new liver carcinogen and microcystin-LR is a tumor promoter rather than a carcinogen, and the need for prevention measures against cyanobacterial toxins is indicated.
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Requirement of Ras for the Activation of Mitogen-Activated Protein Kinase by Calcium Influx, cAMP, and Neurotrophin in Hippocampal Neurons
TLDR
It is demonstrated that Ras transduces signals elicited by a broad range of stimuli to MAP kinase in hippocampal neurons and further suggest that CREB phosphorylation depends on multiple pathways.
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Salmonella type III effector SpvC, a phosphothreonine lyase, contributes to reduction in inflammatory response during intestinal phase of infection
TLDR
It is shown that SpvC can be delivered into the host cell cytoplasm by both SPI‐1 and SPI‐2 T3SSs, and the attenuation of intestinal inflammatory response by SpVC is involved in systemic infection of Salmonella.
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Identification and biochemical analysis of GRIN1 and GRIN2.
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I(2020)T leucine-rich repeat kinase 2, the causative mutant molecule of familial Parkinson's disease, has a higher intracellular degradation rate than the wild-type molecule.
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A new process of cancer prevention mediated through inhibition of tumor necrosis factor alpha expression.
TLDR
Results strongly suggest that inhibition of TNF-alpha mRNA expression and its release is a new process of cancer prevention.
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Discrete roles of cytokines, TNF-α, IL-1, IL-6 in tumor promotion and cell transformation
TLDR
It is concluded that various cytokines have discrete roles in tumor promotion and cell transformation and IL-6 is not the essential cytokine in tumors promotion, since it can be replaced by other cytokines.
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Activation of Protein Kinase C by Mycobacterial Cord Factor, Trehalose 6‐Monomycolate, Resulting in Tumor Necrosis Factor‐α Release in Mouse Lung Tissues
Cord factors are mycoloyl glycolipids in cell walls of bacteria belonging to Actinomycetales, such as Mycobacterium, Nocardia and Rhodococcus. They induce granuloma formation in the lung and…
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Suppression of arachidonic acid cascade-mediated apoptosis in aflatoxin B1-induced rat hepatoma cells by glucocorticoids.
TLDR
Results suggest that AA metabolites are involved in apoptotic K2 cell death elicited by TAM and TGF-beta1, and GCs could act as a tumor promoter in AFB1 hepatocarcinogenesis through the prevention of apoptosis induced by AA metabolites formed in vivo.
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Discrete roles of cytokines, TNF-alpha, IL-1, IL-6 in tumor promotion and cell transformation.
TLDR
It is concluded that various cytokines have discrete roles in tumor promotion and cell transformation and IL-6 is not the essential cytokine in tumors promotion, since it can be replaced by other cytokines.
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