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Development of a condition-specific quality of life measure for patients with dentofacial deformity: I. Reliability of the instrument.
A condition-specific quality of life measure for those patients with severe dentofacial deformity who were requesting orthognathic treatment and to assess the reliability of this instrument, found to divide into four clinically meaningful domains. Expand
Development of a condition-specific quality of life measure for patients with dentofacial deformity: II. Validity and responsiveness testing.
The processes of validity and responsiveness testing of a condition-specific quality of life measure for patients who present with severe dentofacial deformity requesting orthognathic treatment, the so-called OrthognATHic Quality of Life Questionnaire, suggest that the instrument may prove useful in both clinical trials and in quality assurance. Expand
Quality of Life and Its Importance in Orthodontics
Over the last 10–15 years, the terms quality of life (QOL) and health-related quality of life (HRQL) have been seen increasingly in medical literature. Much of the orthodontic treatment that is… Expand
Quality of life and its importance in orthodontics.
Clinicians should be aware of some of the ways in which health-related quality of life may be assessed and study HRQL in orthodontic patients has the potential to provide information about treatment needs and outcomes, and to facilitate improved care. Expand
Gelatinase-B (Matrix Metalloproteinase-9; MMP-9) secretion is involved in the migratory phase of human and murine muscle cell cultures
- M. Lewis, H. Tippett, A. Sinanan, M. Morgan, N. Hunt
- Biology, Medicine
- Journal of Muscle Research & Cell Motility
- 1 April 2000
Investigation of the activity of the gelatinases MMP-2 and 9 by zymography on cell conditioned media in cultures of cells derived from explants of the human masseter muscle and in the murine myoblast cell-line C2C12 shows consistent with the concept that regulation of matrix turnover via M MP-9 may be involved in the events leading to myotube formation, including migration. Expand
Perceptions of outcome following orthognathic surgery.
There was significant improvement in appearance, as well as in self-confidence, overall mood states and the ability to mix socially following joint orthodontic/surgical treatment for the correction of facial deformity. Expand
Craniofacial muscle engineering using a 3-dimensional phosphate glass fibre construct.
Investigation of the use of phosphate-based glass fibres as a potential scaffold material for the in vitro engineering of craniofacial skeletal muscle found a 3-dimensional mesh arrangement was the best at encouraging cell attachment and proliferation. Expand
Human adult craniofacial muscle‐derived cells: neural‐cell adhesion‐molecule (NCAM; CD56)‐expressing cells appear to contain multipotential stem cells
The CD56+ subpopulation within adult human skeletal muscle is heterogeneous and is composed of both lineage‐committed myogenic cells and multipotent cells (the candidate MDSCs), which are able to form non‐muscle tissue such as fat and bone. Expand
Are orthognathic patients different?
This questionnaire-based study investigated the psychological profile of orthognathic patients prior to starting treatment and compared the findings with a control group of non-patients. Comparison… Expand
Identification of matrix metalloproteinases and their tissue inhibitors type 1 and 2 in human masseter muscle.
- A. Singh, Z. Nelson-Moon, G. Thomas, N. Hunt, M. Lewis
- Chemistry, Medicine
- Archives of oral biology
- 1 June 2000
Investigation of in vivo pattern of expression and distribution of MMPs and TIMP proteins in masseter muscle of humans with both normal and abnormal facial forms provides evidence that the mechanisms required for matrix remodelling are present in the human masseter Muscle. Expand