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Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects
Human cytomegalovirus (HCMV) infections of immunocompetent hosts are characterized by a dynamic, life-long interaction in which host immune responses, particularly of T cells, restrain viralExpand
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A conserved tripeptide sorts proteins to peroxisomes
The firefly luciferase protein contains a peroxisomal targeting signal at its extreme COOH terminus (Gould et al., 1987). Site-directed mutagenesis of the luciferase gene reveals that thisExpand
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Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.
Dendritic cells are APCs that are unique in their potency to stimulate proliferation of primary Ag-specific responses in vitro and in vivo. In this study, we demonstrate that dendritic cells canExpand
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Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations
CD4+ T helper (Th) cells can be classified into different types based on their cytokine profile. Cells with these polarized patterns of cytokine production have been termed Th1 and Th2, and can beExpand
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The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model
The dose of foreign antigen can influence whether a cell-mediated or humoral class of immune response is elicited, and this may be largely accounted for by the development of CD4+ T helper cells (Th)Expand
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Reversibility of T helper 1 and 2 populations is lost after long-term stimulation
Commitment of T helper 1 (Th1) or Th2 populations developing during an immune response to a pathogen, or an inappropriate immune response to an allergen or autoantigen, may determine the differenceExpand
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A role for IL-27p28 as an antagonist of gp130-mediated signaling
The heterodimeric cytokine interleukin 27 (IL-27) signals through the IL-27Rα subunit of its receptor, combined with gp130, a common receptor chain used by several cytokines, including IL-6. Notably,Expand
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Depletion of eosinophils in mice through the use of antibodies specific for C‐C chemokine receptor 3 (CCR3)
We have generated rat monoclonal antibodies specific for the mouse eotaxin receptor, C‐C chemokine receptor 3 (CCR3). Several anti‐CCR3 mAbs proved to be useful for in vivo depletion ofExpand
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A Role for IL-27 in Limiting T Regulatory Cell Populations
IL-27 is a cytokine that regulates Th function during autoimmune and pathogen-induced immune responses. Although previous studies have shown that regulatory T cells (Tregs) express the IL-27R, andExpand
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Immunodominance among herpes simplex virus-specific CD8 T cells expressing a tissue-specific homing receptor
  • D. Koelle, Z. Liu, +7 authors L. Corey
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 17 October 2003
The study of immunodominance within microbe-specific CD8 T cell responses has been challenging. We used a previously undescribed approach to create unbiased panels of CD8 cytotoxic T lymphocyteExpand
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