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- Publications
- Influence
Direct effects of diethylstilbestrol on the gene expression of the cholesterol side-chain cleavage enzyme (P450scc) in testicular Leydig cells.
- K. Warita, T. Mitsuhashi, +9 authors N. Hoshi
- Biology, Medicine
- Life sciences
- 28 August 2010
AIMS
To investigate the precise mechanisms underlying the action of estrogenic endocrine disruptors, we evaluated the direct effects of synthetic estrogen diethylstilbestrol (DES) on steroidogenesis… Expand
Effects of exposure to clothianidin on the reproductive system of male quails.
- Junko Tokumoto, Megumi Danjo, +9 authors N. Hoshi
- Biology, Medicine
- The Journal of veterinary medical science
- 2013
Clothianidin (CTD) is a neonicotinoid developed in the 1990s as an insecticide having selective toxicity, but it was later found to cause reproductive abnormalities in rats through oxidative stress.… Expand
Does paternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) affect the sex ratio of offspring?
- Kana Ishihara, K. Warita, Takashi Tanida, T. Sugawara, H. Kitagawa, N. Hoshi
- Biology, Medicine
- The Journal of veterinary medical science
- 25 April 2007
UNLABELLED
In 1976, men who were exposed to the highest concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) after an explosion at a chemical plant near Seveso, Italy, produced more girls… Expand
Fetal and neonatal exposure to three typical environmental chemicals with different mechanisms of action: mixed exposure to phenol, phthalate, and dioxin cancels the effects of sole exposure on mouse…
- Takashi Tanida, K. Warita, +10 authors N. Hoshi
- Chemistry, Medicine
- Toxicology letters
- 25 August 2009
A major question is whether exposure to mixtures of low-dose endocrine disruptors (EDs) having different action mechanisms affects neurodevelopment differently than exposure to EDs individually. We… Expand
Insight into the mechanism of reproductive dysfunction caused by neonicotinoid pesticides.
- N. Hoshi, T. Hirano, +8 authors H. Kitagawa
- Biology, Medicine
- Biological & pharmaceutical bulletin
- 1 September 2014
Neonicotinoids, which were developed in the 1990 s as an insecticide having selective toxicity, were later found to cause reproductive abnormalities in experimental animals. In Japan there is an… Expand
Progression of the dose-related effects of estrogenic endocrine disruptors, an important factor in declining fertility, differs between the hypothalamo-pituitary axis and reproductive organs of male…
- K. Warita, T. Sugawara, +6 authors N. Hoshi
- Biology, Medicine
- The Journal of veterinary medical science
- 1 December 2006
For the purpose of investigation of working mechanisms in endocrine disruptors, we evaluated the dose-related effects of fetal and/or neonatal exposure to an estrogenic compound on the male… Expand
Gene expression of epigenetic regulatory factors related to primary silencing mechanism is less susceptible to lower doses of bisphenol A in embryonic hypothalamic cells.
- K. Warita, T. Mitsuhashi, +4 authors Y. Takeuchi
- Biology, Medicine
- The Journal of toxicological sciences
- 1 April 2013
DNA methyltransferases (DNMTs) are associated with epigenetic regulation of gene expression, and methyl-CpG binding protein 2 (MECP2) acts as a long-range regulator of methylated genes. We evaluated… Expand
Ultrastructural study on the epithelial responses against attachment of indigenous bacteria to epithelial membranes in peyer's patches of rat small intestine.
- Tetsurou Inamoto, Y. Kawata, +6 authors H. Kitagawa
- Biology, Medicine
- The Journal of veterinary medical science
- 1 March 2008
The ultrastructure of epithelial responses against the membrane adhesion of indigenous bacteria was investigated in the follicle-associated epithelium (FAE) of rat small intestine. The most frequent… Expand
When does the sex ratio of offspring of the paternal 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure decrease: in the spermatozoa stage or at fertilization?
- Kana Ishihara, S. Ohsako, +10 authors N. Hoshi
- Biology, Medicine
- Reproductive toxicology
- 2010
Recent animal experiments confirmed that paternal 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure decreases the sex ratio of offspring at birth without altering litter size. However, the timing… Expand
Histoplanimetrical study on the relationship between the cell kinetics of villous columnar epithelial cells and the proliferation of indigenous bacteria in rat small intestine.
- W. Qi, Kenkichi Yamamoto, +7 authors H. Kitagawa
- Biology, Medicine
- The Journal of veterinary medical science
- 1 April 2009
The relationship between the kinetics of villous columnar epithelial cells and the expansion of colonies of indigenous bacteria from the narrow apical portions of intestinal villi was… Expand
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