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Direct evidence for positive selection of skin, hair, and eye pigmentation in Europeans during the last 5,000 y
Strong selection favoring lighter skin, hair, and eye pigmentation has been operating in European populations over the last 5,000 y, providing direct evidence that positive natural selection is responsible for depigmentation within Europe.
Inter- and intra-breed genome-wide copy number diversity in a large cohort of European equine breeds
This work revealed that CNV patterns, in the genome of some European horse breeds, occurred in specific genomic regions, providing support to the hypothesis that high frequency private CNVs residing in genes may potentially be responsible for the diverse phenotypes seen between horse breeds.
Khoe-San Genomes Reveal Unique Variation and Confirm the Deepest Population Divergence in Homo sapiens
All human groups show a reduction in effective population size commencing around the time of the Out-of-Africa migrations, which coincides with changes in the paleoclimate records, changes that potentially impacted all humans at the time.
Northeast African genomic variation shaped by the continuity of indigenous groups and Eurasian migrations
- N. Hollfelder, C. Schlebusch, T. Günther, Hiba Babiker, Hisham Y. Hassan, M. Jakobsson
- Environmental SciencePLoS genetics
- 1 August 2017
A strong genetic divide is found between the populations from the northeastern parts of the region (Nubians, central Arab populations, and the Beja) and populations towards the west and south (Nilotes, Darfur and Kordofan populations).
Patterns of African and Asian admixture in the Afrikaner population of South Africa
In a genome-wide study of 77 Afrikaners, it was found their majority ancestry came from Europeans, but almost all Afrikaans had admixture from non-Europeans, and despite their small founding population, there was no sign of a recent bottleneck in theAfrikaner compared to other European populations.
Megalithic tombs in western and northern Neolithic Europe were linked to a kindred society
- Federico Sánchez-Quinto, H. Malmström, M. Jakobsson
- Environmental ScienceProceedings of the National Academy of Sciences
- 15 April 2019
The genomic investigation provides insight into the people associated with this long-standing megalith funerary tradition, including their social dynamics, and shows kin relations among the buried individuals and an overrepresentation of males, suggesting that at least some of these funerary monuments were used by patrilineal societies.
The deep population history in Africa
- N. Hollfelder, Gwenna Breton, P. Sjödin, M. Jakobsson
- GeographyHuman Molecular Genetics
- 12 January 2021
Abstract Africa is the continent with the greatest genetic diversity among humans and the level of diversity is further enhanced by incorporating non-majority groups, which are often understudied.…
Integrated Molecular Analysis of Undifferentiated Uterine Sarcomas Reveals Clinically Relevant Molecular Subtypes
Molecular evaluation of UUS provides novel insights into the biology, prognosis, phenotype, and possible treatment of these tumors.
The genetic variation of lactase persistence alleles in northeast Africa
A 316bp region involved in regulating the expression of the LCT gene on chromosome 2 is sequenced, which encompasses five polymorphisms that have been associated with LP in Sudanese and South Sudanese populations, resulting in one of the greatest frequencies of LP-variants among all populations across the world.
Population genetic history and patterns of admixture : Examples from northeastern and southern Africa
- N. Hollfelder
The origin of humans lies in Africa, as has been shown by archaeology, paleontology and genetics. Here, we can find the largest genetic diversity and the deepest split among human populations. Afri…