N. Holbrook

Publications180
h-index74
Citations33,696
Highly Influential Citations1,077
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Oxidants, oxidative stress and the biology of ageing
TLDR
Evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span is reviewed.
Gadd153 Sensitizes Cells to Endoplasmic Reticulum Stress by Down-Regulating Bcl2 and Perturbing the Cellular Redox State
TLDR
Gadd153 sensitizes cells to ER stress through mechanisms that involve down-regulation of Bcl2 and enhanced oxidant injury and protected cells from ER stress-induced cell death.
Cellular response to oxidative stress: Signaling for suicide and survival *
TLDR
The various signaling pathways known to be activated in response to oxidative stress in mammalian cells, the mechanisms leading to their activation, and their roles in influencing cell survival are discussed.
Physiological functions of glucocorticoids in stress and their relation to pharmacological actions.
TLDR
It is proposed that stress-induced increases in glucocorticoid levels protect not against the source of stress itself but rather against the body's normal reactions to stress, preventing those reactions from overshooting and themselves threatening homeostasis.
Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury.
TLDR
Insight is provided into mechanisms of MAPK regulation by H2O2 and ERK plays a critical role in cell survival following oxidant injury and is suggested to have a role for growth factor receptors in this activation.
Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate…
TLDR
The results suggest that numerous members of the ATF/CREB family are involved in the cellular stress response, and that regulation of stress-induced biphasic Gadd153 expression in PC12 cells involves the ordered, sequential binding of multiple transcription factor complexes to the C/EBP-ATF composite site.
Requirement for ERK Activation in Cisplatin-induced Apoptosis*
TLDR
It is suggested that ERK activation plays an active role in mediating cisplatin-induced apoptosis of HeLa cells and functions upstream of caspase activation to initiate the apoptotic signal.
HuR Regulates p21 mRNA Stabilization by UV Light
TLDR
These findings indicate that HuR plays a major role in regulating stress-induced p21 expression by enhancing p21 mRNA stability and that these effects are coupled to HuR's elevated presence in the cytoplasm.
The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival.
TLDR
The results suggest that ERK and JNK/SAPK act in opposition to influence cell survival in response to oxidative stress, whereas neither p38 nor NF-kappaB affects the outcome.
Epidermal Growth Factor Receptor-dependent Akt Activation by Oxidative Stress Enhances Cell Survival*
TLDR
The results suggest that H2O2activates Akt via an EGFR/PI3-K-dependent pathway and that elevated Akt activity confers protection against oxidative stress-induced apoptosis.
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