Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Oxidants, oxidative stress and the biology of ageing
- T. Finkel, N. Holbrook
- Biology, Medicine
- Nature
- 9 November 2000
Living in an oxygenated environment has required the evolution of effective cellular strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen species. Here we review… Expand
Gadd153 Sensitizes Cells to Endoplasmic Reticulum Stress by Down-Regulating Bcl2 and Perturbing the Cellular Redox State
- K. McCullough, J. Martindale, L. O. Klotz, T. Y. Aw, N. Holbrook
- Biology, Medicine
- Molecular and Cellular Biology
- 15 February 2001
ABSTRACT gadd153, also known as chop, is a highly stress-inducible gene that is robustly expressed following disruption of homeostasis in the endoplasmic reticulum (ER) (so-called ER stress).… Expand
Cellular response to oxidative stress: Signaling for suicide and survival *
- J. Martindale, N. Holbrook
- Biology, Medicine
- Journal of cellular physiology
- 1 July 2002
Reactive oxygen species (ROS), whether produced endogenously as a consequence of normal cell functions or derived from external sources, pose a constant threat to cells living in an aerobic… Expand
Physiological functions of glucocorticoids in stress and their relation to pharmacological actions.
- A. Munck, P. Guyre, N. Holbrook
- Biology, Medicine
- Endocrine reviews
- 1984
Almost any kind of threat to homeostasis or stress will cause plasma glucocorticoid levels to rise. The increased levels have traditionally been ascribed the physiological function of enhancing the… Expand
Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury.
- K. Guyton, Y. Liu, M. Gorospe, Q. Xu, N. Holbrook
- Biology, Medicine
- The Journal of biological chemistry
- 23 February 1996
The mitogen-activated protein kinase (MAPK) family is comprised of key regulatory proteins that control the cellular response to both proliferation and stress signals. In this study we investigated… Expand
Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate…
- T. W. Fawcett, J. Martindale, K. Guyton, T. Hai, N. Holbrook
- Chemistry, Medicine
- The Biochemical journal
- 1 April 1999
Gadd153, also known as chop, encodes a member of the CCAAT/enhancer-binding protein (C/EBP) transcription factor family and is transcriptionally activated by cellular stress signals. We recently… Expand
Requirement for ERK Activation in Cisplatin-induced Apoptosis*
- X. Wang, J. Martindale, N. Holbrook
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 15 December 2000
Cisplatin activates multiple signal transduction pathways involved in coordinating cellular responses to stress. Here we demonstrate a requirement for extracellular signal-regulated protein kinase… Expand
The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival.
- X. Wang, J. Martindale, Y. Liu, N. Holbrook
- Chemistry, Medicine
- The Biochemical journal
- 15 July 1998
The mammalian response to stress is complex, often involving multiple signalling pathways that act in concert to influence cell fate. To examine potential interactions between the signalling… Expand
Epidermal Growth Factor Receptor-dependent Akt Activation by Oxidative Stress Enhances Cell Survival*
- X. Wang, K. McCullough, T. F. Franke, N. Holbrook
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 12 May 2000
The serine/threonine kinase Akt (also known as protein kinase B) is activated in response to various stimuli by a mechanism involving phosphoinositide 3-kinase (PI3-K). Akt provides a survival signal… Expand
Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents.
- A. J. Fornace, D. Nebert, +4 authors N. Holbrook
- Biology, Medicine
- Molecular and cellular biology
- 1 October 1989
More than 20 different cDNA clones encoding DNA-damage-inducible transcripts in rodent cells have recently been isolated by hybridization subtraction (A. J. Fornace, Jr., I. Alamo, Jr., and M. C.… Expand