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TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation.
TLDR
It is demonstrated for the first time that TNF-alpha-induced increase in Caco-2 TJ permeability was mediated by NF-kappa B activation.
Ethanol modulation of intestinal epithelial tight junction barrier.
TLDR
It is indicated that ethanol at low noncytotoxic doses causes a functional and structural opening of the Caco-2 intestinal epithelial TJ barrier by activating MLCK.
TNF-α-induced increase in intestinal epithelial tight junction permeability requires NF-κB activation
Crohn's disease (CD) patients have an abnormal increase in intestinal epithelial permeability. The defect in intestinal tight junction (TJ) barrier has been proposed as an important etiologic facto...
Antigenic Profiling of Glioma Cells to Generate Allogeneic Vaccines or Dendritic Cell–Based Therapeutics
Purpose: Allogeneic glioma cell lines that are partially matched to the patient at class I human leukocyte antigen (HLA) loci and that display tumor-associated antigens (TAA) or antigenic precursors
Mechanism of extracellular calcium regulation of intestinal epithelial tight junction permeability: Role of cytoskeletal involvement
TLDR
It is suggested that the CFS‐induced alteration of TJ proteins and functional increase in TJ permeability was mediated by Caco‐2 MLCK activation and the resultant contraction of the peri‐junctionally located actin‐myosin filaments.
Macrophage colony stimulating factor: not just for macrophages anymore! A gateway into complex biologies.
TLDR
The mechanisms of the biological effects of the membrane-bound M-CSF reveal that this cytokine is unexpectedly involved in many complex molecular events.
Immunoglobulins from patients with Graves' disease induce hyaluronan synthesis in their orbital fibroblasts through the self-antigen, insulin-like growth factor-I receptor.
TLDR
The observation that hyaluronan production is induced by GD-IgG in fibroblasts suggests that the IGF-I receptor and its activating antibodies may represent a key pathway through which important pathogenic events in thyroid-associated ophthalmopathy are mediated.
Evidence for an Association between Thyroid-Stimulating Hormone and Insulin-Like Growth Factor 1 Receptors: A Tale of Two Antigens Implicated in Graves’ Disease1
TLDR
It is suggested that IGF-1R might mediate some TSH-provoked signaling and that this receptor associates with IGF- 1R in situ and together may comprise a functional complex in thyroid and orbital tissue.
Cytochalasin B modulation of Caco-2 tight junction barrier: role of myosin light chain kinase.
  • T. Ma, N. Hoa, +4 authors M. Merryfield
  • Biology, Medicine
    American journal of physiology. Gastrointestinal…
  • 1 November 2000
TLDR
Findings suggested that Cyto B-induced increase in Caco-2 TJ permeability is regulated by MLCK activation.
Tumor antigen precursor protein profiles of adult and pediatric brain tumors identify potential targets for immunotherapy
TLDR
The potential TAA targets identified from the TAPP profiles of 31 genes associated with adult and pediatric brain tumors may help investigators select specific target antigens for developing dendritic cell- or peptide-based vaccines or T cell-based immunotherapeutic approaches against brain tumors.
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