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Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis.
We have developed a real-time quantitative PCR assay to measure the concentration of fetal DNA in maternal plasma and serum. Our results show that fetal DNA is present in high concentrations in… Expand
Quantitative analysis of cell-free Epstein-Barr virus DNA in plasma of patients with nasopharyngeal carcinoma.
Using real-time quantitative PCR, cell-free EBV DNA was detectable in the plasma of 96% (55 of 57) of nasopharyngeal carcinoma (NPC) patients (median concentration, 21058 copies/ml) and 7% (3 of 43)… Expand
Rapid clearance of fetal DNA from maternal plasma.
- Y. Lo, J. Zhang, T. Leung, T. Lau, A. M. Chang, N. Hjelm
- Medicine, Biology
- American journal of human genetics
Fetal DNA has been detected in maternal plasma during pregnancy. We investigated the clearance of circulating fetal DNA after delivery, using quantitative PCR analysis of the sex-determining region Y… Expand
Prenatal diagnosis of fetal RhD status by molecular analysis of maternal plasma.
BACKGROUND The ability to determine fetal RhD Status noninvasively is useful in the treatment of RhD-sensitized pregnant women whose partners are heterozygous for the RhD gene. The recent… Expand
Detection of aberrant p16 methylation in the plasma and serum of liver cancer patients.
We have studied the feasibility of detecting tumor-associated aberrant p16 methylation in the circulation of patients with hepatocellular carcinoma (HCC). We extracted DNA from the tumor tissues and… Expand
Quantitative and temporal correlation between circulating cell-free Epstein-Barr virus DNA and tumor recurrence in nasopharyngeal carcinoma.
Recently, cell-free EBV DNA has been detected in the plasma and serum of patients with nasopharyngeal carcinoma (NPC). We studied the relationship between plasma/serum EBV DNA and tumor recurrence.… Expand
Benefits and drawbacks of telemedicine
- N. Hjelm
- Journal of telemedicine and telecare
- 1 March 2005
Telemedicine is a vast subject, but as yet there are limited data on the clinical effectiveness and cost-effectiveness of most telemedicine applications. As a result, objective information about the… Expand
Plasma DNA as a prognostic marker in trauma patients.
BACKGROUND Recently, much interest has developed in the potential use of plasma DNA as a diagnostic and monitoring tool. We hypothesized that plasma DNA is increased in patients with trauma and may… Expand
Increased fetal DNA concentrations in the plasma of pregnant women carrying fetuses with trisomy 21.
BACKGROUND The recent discovery of the presence of circulating cell-free fetal DNA in maternal plasma opens up new prenatal diagnostic applications and provides new avenues for clinical… Expand