• Publications
  • Influence
Molecular Cloning and Expression of Two Distinct Human Chondroitin 4-O-Sulfotransferases That Belong to the HNK-1 Sulfotransferase Gene Family*
TLDR
Northern analysis demonstrated that the transcript for C4 ST-1 is predominantly expressed in peripheral leukocytes and hematopoietic tissues while theC4ST-2 transcript is more widely expressed in various tissues, indicating C4STs play complementary roles in chondroitin and dermatan sulfate synthesis in different tissues. Expand
The ST3Gal-I sialyltransferase controls CD8+ T lymphocyte homeostasis by modulating O-glycan biosynthesis.
TLDR
Control of core 1 O-glycan sialylation in T lymphocytes by ST3Gal-I comprises a homeostatic mechanism that eliminatesCD8+ T cells by apoptosis while facilitating the production of viable CD8+ memory T cells. Expand
Novel Sulfated Lymphocyte Homing Receptors and Their Control by a Core1 Extension β1,3-N-Acetylglucosaminyltransferase
TLDR
Core1-beta 3GlcNAcT and its cognate extended core1 O-glycans are identified as essential participants in the expression of the MECA-79-positive, HEV-specific L-selectin ligands required for lymphocyte homing. Expand
A novel, high endothelial venule-specific sulfotransferase expresses 6-sulfo sialyl Lewis(x), an L-selectin ligand displayed by CD34.
TLDR
A novel L-selectin ligand sulfotransferase, termed LSST, is described that directs the synthesis of the 6-sulfo sialyl Lewis(x) on L- selectin counterreceptors CD34, GlyCAM-1, and MAdCam-1 and enhances L- Selectin-mediated adhesion under shear compared to nonsulfated controls. Expand
N-acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules
TLDR
The essential function of GlcNAc6ST-1 and Glcnac6 ST-2 in L-selectin ligand biosynthesis in high endothelial venules and their importance in immune surveillance are demonstrated. Expand
A novel strategy for evasion of NK cell immunity by tumours expressing core2 O‐glycans
TLDR
It is reported that upregulation of C2GnT is closely correlated with progression of bladder tumours and that C2 GnT‐expressing bladder tumour cells use a novel strategy to increase their metastatic potential and revealed the molecular mechanism of the immune evasion by C2gnT expression. Expand
Extended Core 1 and Core 2 Branched O-Glycans Differentially Modulate Sialyl Lewis x-type L-selectin Ligand Activity*
TLDR
Results indicate that sialyl Lewis x in extended core 1 O-glycans can function as an L-selectin ligand and is potentially involved in neutrophil adhesion on neutrophils bound to activated endothelial cells. Expand
Carbohydrate-modifying Sulfotransferases: Structure, Function, and Pathophysiology*
TLDR
These studies demonstrate that sulfotransferases also have the same type II membrane topology as other Golgi enzymes such as glycosyltransferases. Expand
Human Corneal GlcNAc 6-O-Sulfotransferase and Mouse Intestinal GlcNAc 6-O-Sulfotransferase Both Produce Keratan Sulfate*
TLDR
Results indicate that hCGn6ST transfers sulfate to C-6 of GlcNAc in keratan sulfate in the cornea, and suggests that mouse intestinal Glc NAc 6-O-sulfotransferase is the orthologue of hCGN6ST and functions as a sulfotransFERase to produce keratan sulphate inThe cornea. Expand
Altered T cell surface glycosylation in HIV-1 infection results in increased susceptibility to galectin-1-induced cell death.
TLDR
It is shown that HIV-1 infection of T cells results in altered glycosylation of cell surface glycoproteins; specifically, it decreased sialylation and increased expression of core 2 O-glycans and galectin-1 is an endogenous human lectin that recognizes these types of gly cosylation changes and induces cell death of activated lymphocytes. Expand
...
1
2
...