A Meta-Analysis of Cytokines in Major Depression
Peripheral cytokine and chemokine alterations in depression: a meta‐analysis of 82 studies
To conduct a systematic review and meta‐analysis of studies that measured cytokine and chemokine levels in individuals with major depressive disorder (MDD) compared to healthy controls (HCs).
A Meta-Analysis of Cytokines in Alzheimer's Disease
Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits
- Jennifer R Glass, K. Lanctôt, N. Herrmann, B. Sproule, U. Busto
- Medicine, PsychologyBMJ : British Medical Journal
- 11 November 2005
Improvements in sleep with sedative use are statistically significant, but the magnitude of effect is small, and the increased risk of adverse events is statistically significant and potentially clinically relevant in older people at risk of falls and cognitive impairment.
Antipsychotic Drug Use and Mortality in Older Adults with Dementia
This large, population-based study from Canada assessed the risk for death after dispensation of antipsychotics in older adults with dementia and concluded that improvements in behavioral symptoms with antipsychotic drug treatment do not necessarily lead to improvements in overall quality of life for patients or their caregivers.
A validation study of The Geriatric Depression Scale short form
The Geriatric Depression Scale short form appears to be a useful, valid screening instrument in this population of geriatric affective disorders patients.
Medical illness and the risk of suicide in the elderly.
- D. Juurlink, N. Herrmann, J. Szalai, A. Kopp, D. Redelmeier
- Medicine, PsychologyArchives of Internal Medicine
- 14 June 2004
Treatment for multiple illnesses was strongly related to a higher risk of suicide in elderly patients, and many common illnesses are independently associated with an increased risk of Suicide in the elderly.
Efficacy and safety of cholinesterase inhibitors in Alzheimer's disease: a meta-analysis.
- K. Lanctôt, N. Herrmann, T. Einarson
- MedicineCMAJ : Canadian Medical Association journal…
- 16 September 2003
A meta-analysis of randomized, double-blind, placebo-controlled, parallel-group trials of currently marketed ChEIs, used in therapeutic doses for at least 12 weeks, results in a modest but significant therapeutic effect and modestly but significantly higher rates of adverse events and discontinuation of treatment.
Peripheral Alterations in Cytokine and Chemokine Levels After Antidepressant Drug Treatment for Major Depressive Disorder: Systematic Review and Meta-Analysis
An updated meta-analysis of studies that measured peripheral levels of cytokines and chemokines during antidepressant treatment in patients with MDD indicates that antidepressants decrease several markers of peripheral inflammation, but does not provide evidence that reductions in peripheral inflammation are associated with antidepressant treatment response.