Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type…
The results suggest that an at-risk haplotype of common variants located in the promoter and rare mutations in exon 3 contribute to the variation of the adipocyte-secreted adiponectin hormone level, and may be part of the genetic determinants for T2D in the French Caucasian population.
Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function.
- B. Neve, M. Fernández-Zapico, P. Froguel
- Biology, MedicineProceedings of the National Academy of Sciences…
- 29 March 2005
Functional and genetic analyses reveal that KLF11 plays a role in the regulation of pancreatic beta cell physiology, and its variants may contribute to the development of diabetes.
Impact of the Peroxisome Proliferator Activated Receptor γ2 Pro12Ala polymorphism on adiposity, lipids and non-insulin-dependent diabetes mellitus
The results suggest that genetic variability of PPARγ2 affects body weight control and lipid homeostasis in humans and do not support a significant role for the PPAR γ2 Pro12Ala polymorphism in the aetiology of NIDDM.
Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity
These data clarify the contribution of the 5′-ACDC SNPs to the risk of diabesity and suggest for the first time a different genetic profile of type 2 diabetes in morbidly obese patients compared with in less obese individuals.
A genetic polymorphism of the peroxisome proliferator-activated receptor gamma gene influences plasma leptin levels in obese humans.
Results show that in obese subjects variability within the PPAR gamma gene locus is associated with circulating leptin levels and may modify the relationship betweenptin levels and adipose tissue mass.
An uncoupling protein 3 gene polymorphism associated with a lower risk of developing Type II diabetes and with atherogenic lipid profile in a French cohort
The recently reported UCP3–55 C/T polymorphism was associated with a higher atherogenic profile and modified the risk for the development of Type II diabetes.
Polymorphisms in the promoter regions of MMP-2, MMP-3, MMP-9 and MMP-12 genes as determinants of aneurysmal coronary artery disease.
Beta2-adrenoceptor gene polymorphism, body weight, and physical activity.
Overall alcohol intake, beer, wine, and systemic markers of inflammation in western Europe: results from three MONICA samples (Augsburg, Glasgow, Lille)
Association between beta-1 and beta-2 adrenergic receptor gene polymorphisms and the response to beta-blockade in patients with stable congestive heart failure
Heart rate and LVEF responses to &bgr;-blockade were not associated with the & bgr;1AR or the &b gr;2AR polymorphisms, and genetic variations in the AR gene did not explain the interindividual variability in the response to the drug.