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Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina.
- M. Hojo, T. Ohtsuka, N. Hashimoto, G. Gradwohl, F. Guillemot, R. Kageyama
- Biology, Medicine
- 15 June 2000
It is found that, in mouse retina, the bHLH gene Hes5 was specifically expressed by differentiating Müller glial cells and that misexpression of Hes5 with recombinant retrovirus significantly increased the population ofglial cells at the expense of neurons. Expand
Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions.
LOX-1 may play important roles in Ox-LDL uptake and subsequent functional alteration in the luminal endothelium in early atherosclerotic lesions and in intimal neovascular endothelial cells in advanced plaques. Expand
Oxidized LDL Modulates Bax/Bcl-2 Through the Lectinlike Ox-LDL Receptor-1 in Vascular Smooth Muscle Cells
- H. Kataoka, N. Kume, +5 authors T. Kita
- Biology, Medicine
- Arteriosclerosis, thrombosis, and vascular…
- 1 June 2001
Oxidized low density lipoprotein (Ox-LDL) induces apoptosis in vascular smooth muscle cells (VSMCs), which may increase atherosclerotic plaque instability, and a neutralizing anti–LOX-1 monoclonal antibody, which can block LOX- 1–mediated cellular uptake of Ox- LDL, prevented the Ox-LDl–induced apoptosisIn BASMCs. Expand
Bone regeneration by transforming growth factor beta1 released from a biodegradable hydrogel.
- M. Yamamoto, Y. Tabata, L. Hong, S. Miyamoto, N. Hashimoto, Y. Ikada
- Chemistry, Medicine
- Journal of controlled release : official journal…
- 14 February 2000
The gelatin hydrogel is a promising matrix of TGF-beta1 release to induce skull bone regeneration and indicates that the sustained release from the hydrogels with suitable in vivo degradability is necessary to effectively enhance its osteoinductive function. Expand
The Basic Helix-Loop-Helix Gene hesr2 Promotes Gliogenesis in Mouse Retina
- T. Satow, S. Bae, +6 authors R. Kageyama
- Biology, Medicine
- The Journal of Neuroscience
- 15 February 2001
It is indicated that, among structurally related hesrgenes, only hesr2 promotes glial versus neuronal cell fate specification in the retina and that antagonistic regulation between Hesr2 and Mash1–Math3 may determine the ratios of neurons and glia. Expand
Infarct tolerance against temporary focal ischemia following spreading depression in rat brain
The preconditioning method was demonstrated to limit the size of cerebral infarct after temporary focal cerebral ischemia; tolerance for cerebral infArct developed after an extended interval following a long period of spreading depression. Expand
Platelet-Derived Growth Factor-BB, but Not -AA, Prevents Delayed Neuronal Death after Forebrain Ischemia in Rats
- K. Iihara, N. Hashimoto, T. Tsukahara, M. Sakata, H. Yanamoto, T. Taniguchi
- Journal of cerebral blood flow and metabolism…
- 1 October 1997
Signs of neuroprotective actions of PDGF-BB are established in ischemic neuronal damage in rats with focal ischemia, and dose-dependent effects are established. Expand
Induction of infarct tolerance by platelet-derived growth factor against reversible focal ischemia.
The potent neuroprotective effect of PDGF-BB on global ischemia was also demonstrated in the focal ischemIA model, however, prolonged intracerebral infusion for 7 to 14 days was necessary to achieve a significant reduction of infarct volume. Expand
Effects of brain-derived neurotrophic factor on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in monkeys.
Severe neuronal cell loss in the substantia nigra was observed in animals with severe parkinsonism (those in the non-BDNF group), whereas significantly less damage was observed during the 2-week observation period in the BDNF group. Expand
Role of transforming growth factor-beta1 in the pathogenesis of moyamoya disease.
It is suggested that TGFbeta1 is associated with the pathogenesis of moyamoya disease, including abundant neovascularization, although their findings do not necessarily mean that T GF beta1 is a causative factor in this disease. Expand