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Gastroprotective effect of desmosdumotin C isolated from Mitrella kentii against ethanol-induced gastric mucosal hemorrhage in rats: possible involvement of glutathione, heat-shock protein-70,
The current study reveals that DES demonstrated gastroprotective effects which could be attributed to its antioxidant effect, activation of HSP-70 protein, intervention with COX-2 inflammatory pathway and potent anti H pylori effect. Expand
β-Mangostin induces p53-dependent G2/M cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway and NfkB suppression in MCF-7 cells
The results demonstrated that the βM induced anti-proliferative effect, leading to G2/M phase cell cycle arrest and apoptosis through both the extrinsic and mitochondrial pathways with the involvement of the multiple pro and anti-apoptosis and NF-kB signalling pathways. Expand
β Mangostin suppress LPS-induced inflammatory response in RAW 264.7 macrophages in vitro and carrageenan-induced peritonitis in vivo.
The in vivo analysis showed that after four hours of peritonitis, βM was unable to reduce vascular permeability, yet could decrease the total leukocyte migration; particularly, neutrophils, which supports the traditional use of Garcinia mangostana fruit hull for treatment of inflammatory conditions. Expand
Prenylated flavones from Artocarpus altilis
Six prenylated flavones, including one new compound, were isolated and identified from the stem bark extracts of Artocarpus altilis by spectroscopic methods and comparison with published data for the known compounds. Expand
α-Mangostin from Garcinia mangostana Linn: An updated review of its pharmacological properties
Abstract Over the past decades, various studies have highlighted the pure natural compound, α -mangostin as their main topic. The compound’s pre-clinical and pharmacological properties have beenExpand
New diprenylated dihyrochalcones from leaves of Artocarpus elasticus
Abstract Two new diprenylated dihydrochalcones, elastichalcone A 1 and elastichalcone B 2 and three known compounds were isolated from the leaves of Artocarpus elasticus. Their structures wereExpand
Two new xanthones from Artocarpus obtusus
Two new xanthones, pyranocycloartobiloxanthone A and dihydroartoindonesianin C, isolated from the stem bark of Artocarpus obtusus Jarrett by chromatographic separation showed strong free radical scavenging activity by using DPPH assay as well as cytotoxicity towards K562, HL-60, and MCF7 cell lines. Expand
Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens
The results demonstrate that the AM isolated from C. arborescens inhibited the proliferation of MDA-MB-231 cells, leading to cell cycle arrest and programmed cell death, which was suggested to occur through both the extrinsic and intrinsic apoptosis pathways with involvement of the NF-κB and HSP70 signaling pathways. Expand
A New Pyranoxanthone from the Stem Bark of Calophyllum buxifolium
A new pyranoxanthone, buxixanthone (1), was isolated from the stem bark of Calophyllum buxifolium along with three other chemical constituents, ananixanthone (2), pyranojacareubin (3), andExpand
Involvement of NF-κB and Bcl2/Bax signaling pathways in the apoptosis of MCF7 cells induced by a xanthone compound Pyranocycloartobiloxanthone A.
The results showed that PA possesses the characteristics of selectively inducing cell death of tumor cells as no inhibition was observed in non-tumorigenic cells even at 30 μg/ml. Expand