β Mangostin suppress LPS-induced inflammatory response in RAW 264.7 macrophages in vitro and carrageenan-induced peritonitis in vivo.
New diprenylated dihyrochalcones from leaves of Artocarpus elasticus
α-Mangostin from Garcinia mangostana Linn: An updated review of its pharmacological properties
Gastroprotective effect of desmosdumotin C isolated from Mitrella kentii against ethanol-induced gastric mucosal hemorrhage in rats: possible involvement of glutathione, heat-shock protein-70,…
- H. M. A. Sidahmed, A. Azizan, J. Vadivelu
- Medicine, BiologyBMC Complementary and Alternative Medicine
- 19 July 2013
The current study reveals that DES demonstrated gastroprotective effects which could be attributed to its antioxidant effect, activation of HSP-70 protein, intervention with COX-2 inflammatory pathway and potent anti H pylori effect.
β-Mangostin induces p53-dependent G2/M cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway and NfkB suppression in MCF-7 cells
The molecular mechanism of the anticancer effect of Artonin E in MDA-MB 231 triple negative breast cancer cells
Artonin E showed the potential as a promising candidate to combat the aggressive triple negative breast cancer by effectively relinquishing MDA-MB 231 breast cancer cells of their apoptosis evading capacity, causing a half-maximal growth inhibition at low concentrations.
Two new xanthones from Artocarpus obtusus
Two new xanthones, pyranocycloartobiloxanthone A and dihydroartoindonesianin C, isolated from the stem bark of Artocarpus obtusus Jarrett by chromatographic separation showed strong free radical scavenging activity by using DPPH assay as well as cytotoxicity towards K562, HL-60, and MCF7 cell lines.
Prenylated flavones from Artocarpus altilis
Six prenylated flavones, including one new compound, were isolated and identified from the stem bark extracts of Artocarpus altilis by spectroscopic methods and comparison with published data for the known compounds.
Involvement of NF-κB and Bcl2/Bax signaling pathways in the apoptosis of MCF7 cells induced by a xanthone compound Pyranocycloartobiloxanthone A.
Liriodenine, an aporphine alkaloid from Enicosanthellum pulchrum, inhibits proliferation of human ovarian cancer cells through induction of apoptosis via the mitochondrial signaling pathway and…
- Noraziah Nordin, N. Majid, N. Hashim, M. A. Rahman, Z. Hassan, H. Ali
- Biology, ChemistryDrug Design, Development and Therapy
- 10 March 2015
It is shown that liriodenine inhibits progression of the CAOV-3 cell cycle in S phase and could be considered as a promising anticancer agent.