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Genome sequence of the human malaria parasite Plasmodium falciparum
The genome sequence of P. falciparum clone 3D7 is reported, which is the most (A + T)-rich genome sequenced to date and is being exploited in the search for new drugs and vaccines to fight malaria. Expand
The Genome of the African Trypanosome Trypanosoma brucei
Comparisons of the cytoskeleton and endocytic trafficking systems of Trypanosoma brucei with those of humans and other eukaryotic organisms reveal major differences. Expand
The genome of the social amoeba Dictyostelium discoideum
A proteome-based phylogeny shows that the amoebozoa diverged from the animal–fungal lineage after the plant–animal split, but Dictyostelium seems to have retained more of the diversity of the ancestral genome than have plants, animals or fungi. Expand
Accurate determination of microbial diversity from 454 pyrosequencing data
We present an algorithm, PyroNoise, that clusters the flowgrams of 454 pyrosequencing reads using a distance measure that models sequencing noise. This infers the true sequences in a collection ofExpand
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus and revealed temperature-dependent expression of distinct sets of genes, as well as 700 A. fumigatus genes not present or significantly diverged in the closely related sexual species Neosartorya fischeri, many of which may have roles in the pathogenicity phenotype. Expand
A Comprehensive Survey of the Plasmodium Life Cycle by Genomic, Transcriptomic, and Proteomic Analyses
It is observed posttranscriptional gene silencing through translational repression of messenger RNA during sexual development, and a 47-base 3′ untranslated region motif is implicated in this process. Expand
Analysis of the bread wheat genome using whole genome shotgun sequencing
It is shown that the hexaploid genome is highly dynamic, with significant loss of gene family members on polyploidization and domestication, and an abundance of gene fragments. Expand
Insight into biases and sequencing errors for amplicon sequencing with the Illumina MiSeq platform
A large study on the error patterns for the MiSeq based on 16S rRNA amplicon sequencing data is conducted and it is shown that the library preparation method and the choice of primers are the most significant sources of bias and cause distinct error patterns. Expand
An ancestral oomycete locus contains late blight avirulence gene Avr3a, encoding a protein that is recognized in the host cytoplasm.
The oomycete Phytophthora infestans causes late blight, the potato disease that precipitated the Irish famines in 1846 and 1847, and it is suggested that Avr3a has undergone gene duplication and that an allele evading recognition by R3a arose under positive selection. Expand
Regulation of Sexual Development of Plasmodium by Translational Repression
Translational repression and mRNA turnover were shown to influence stage-specific gene expression in the protozoan Plasmodium and the DDX6-class RNA helicase, DOZI, is found in a complex with mRNA species in cytoplasmic bodies of female, blood-stage gametocytes. Expand