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Humoral immunity in experimental syphilis. I. The demonstration of resistance conferred by passive immunization.
The failure of passive immunization to provide complete protection was evident not only in the development of the atypical lesions, but also in the demonstration of disseminated infection in the tissues of three of the four surviving animals 7 months after challenge.
Humoral immune response in experimental syphilis to polypeptides of Treponema pallidum.
- P. Hanff, N. H. Bishop, J. N. Miller, M. Lovett
- Biology, MedicineJournal of immunology
- 1 October 1983
The results suggest that after intratesticular challenge a vigorous IgG response to T. pallidum polypeptides can be detected and the potential role of humoral immune mechanisms in the development and maintenance of immunity is discussed.
Humoral immunity in experimental syphilis. II. The relationship of neutralizing factors in immune serum to acquired resistance.
A relatively close quantitative correlation was shown between the development of resistance to symptomatic reinfection and the appearance and persistence of both TPI antibody and neutralizing serum factor(s).
Microassay for immunoglobulin G antibodies to Treponema pallidum with radioiodinated protein A from staphylococcus aureus: immunoglobulin G response in experimental syphilis in rabbits
- P. Zeltzer, J. Pepose, N. H. Bishop, J. N. Miller
- Biology, MedicineInfection and immunity
- 1 July 1978
Radioiodinated staphylococcal protein A was used to detect the immunoglobulin G (IgG) antibody response to Treponema pallidum in experimental syphilis and demonstrated maximum binding and the highest immune binding ratio (15:1) with a 60-min incubation each for antibody and (125)I-SpA, respectively.
The Humoral Immune Response in Rabbits Infected with Treponema pallidum: Comparison of Antibody Levels Measured by the Staphylococcal Protein A‐IgG (SPA‐TP) Microassay with VDRL, FTA‐Abs, and TPI…
- J. Pepose, N. H. Bishop, S. Feigenbaum, J. N. Miller, P. Zeltzer
- Biology, MedicineSexually transmitted diseases
- 1 July 1980
Preliminary evidence indicated that the antibody detected by the SPA-TP microassay may correlate quantitatively with the state of host immunity as determined by in vivo challenge; if this finding is confirmed, this finding could be applied for assessment of the immune status in syphilis.