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Hidden Killers: Human Fungal Infections
- Gordon D. Brown, D. Denning, N. Gow, S. Levitz, M. Netea, T. C. White
- Biology, MedicineScience Translational Medicine
- 19 December 2012
The importance of fungi as human pathogens is highlighted and the challenges the authors face in combating the devastating invasive infections caused by these microorganisms are discussed, in particular in immunocompromised individuals.
An integrated model of the recognition of Candida albicans by the innate immune system
The fungal pathogen Candida albicans is used as a model for the complex interaction that exists between the host pattern-recognition systems and invading microbial pathogens.
Candida orthopsilosis and Candida metapsilosis spp. nov. To Replace Candida parapsilosis Groups II and III
- A. Tavanti, A. Davidson, N. Gow, M. Maiden, F. Odds
- BiologyJournal of Clinical Microbiology
- 1 January 2005
Cluster analysis of sequence polymorphisms from COX3, SADH, and SYA1, which were common to the three groups, consistently separated the isolates into three distinct sets, suggest the subgroups should be afforded species status.
Evolution of pathogenicity and sexual reproduction in eight Candida genomes
There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence in Candida albicans species.
The distinct morphogenic states of Candida albicans.
Antifungal agents: mechanisms of action.
Yeast-enhanced green fluorescent protein (yEGFP): a reporter of gene expression in Candida albicans.
YEGFP3 can be used as a versatile reporter of gene expression in C. albicans and Saccharomyces cerevisiae and the optimized GFP described here should have broad applications in these and other fungal species.
Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors.
It is demonstrated that cytokine production by human mononuclear cells or murine macrophages was markedly reduced when stimulated by C. albicans mutants defective in mannosylation and recognition of C.Albicans by monocytes/macrophages is mediated by 3 recognition systems of differing importance, each of which senses specific layers of the C. Albicans cell wall.
Candida albicans morphogenesis and host defence: discriminating invasion from colonization
The properties of yeast cells and hyphae that are relevant to their interaction with the host, and the immunological mechanisms that differentially recognize colonizing versus invading C. albicans are described.
Molecular Phylogenetics of Candida albicans
Analysis of data on multilocus sequence typing, ABC typing, mating type-like locus (MAT) status, and antifungal susceptibility for a panel of 1,391 Candida albicans isolates suggested that isolates had mixed evolutionary histories resembling those of a sexually reproducing species.