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Metabolism of the human immunodeficiency virus protease inhibitors indinavir and ritonavir by human intestinal microsomes and expressed cytochrome P4503A4/3A5: mechanism-based inactivation of
The essential role of the CYP3A subfamily in the metabolism of both protease inhibitors by the small intestine and the improved bioavailability and pharmacokinetics of ritonavir and the sustained elevation of blood levels of other, concomitantly administered, substrates of CYP 3A is shown. Expand
Single- and multiple-dose pharmacokinetics of ziprasidone under non-fasting conditions in healthy male volunteers.
Ziprasidone is characterized by a predictable pharmacokinetic profile resulting in symptoms that reflect its pharmacological action. Expand
Disposition of valproic acid in the rat: dose-dependent metabolism, distribution, enterohepatic recirculation and choleretic effect.
A specific gas chromatographic assay has been developed for measurement of valproic acid (VPA) and its major conjugated metabolites and sodium VPA caused a dose-dependent stimulation of bile flow, the magnitude and duration of which closely followed the blood concentration of VPA. Expand
Metabolism of rifabutin in human enterocyte and liver microsomes: Kinetic parameters, identification of enzyme systems, and drug interactions with macrolides and antifungal agents
Evidence is provided that CYP3A4 and cholinesterase are major enzymes that biotransform rifabutin in humans and that intestinal CYP 3A4 contributes significantly to rifAButin presystemic first‐pass metabolism and drug interactions with macrolide and antifungal agents. Expand
Clinical eftects and pharmacokinetics of racemic methadone and its optical isomers
D,l‐Methadone administeredfrequently for pain may have cumulative effects on respiratory control and ability to excrete a water load, and whole blood drug concentration correlated weil with respiratory depression and miosis for 1‐ and d, l‐methadones. Expand
The rate of decline of diphenylhydantoin in human plasma
Saturation, autoinduction, or product inhibition, singly or in combination, of the drug‐metabolizing enzyme system are possible mechanisms involved in the dose dependency and nonexponential decline of plasma diphenylhydantoin concentration. Expand
Reye-like syndrome associated with valproic acid therapy.
Prevention of murine cardiac allograft rejection with gallium nitrate. Comparison with anti-CD4 monoclonal antibody.
In general, both GN and anti-CD4 mAb promoted long-term allografted survival, but these allografts displayed the histopathologic signs of ongoing inflammation and chronic allog graft rejection. Expand