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Immunogenicity and impact on disease activity of influenza and pneumococcal vaccines in systemic lupus erythematosus: a systematic literature review and meta-analysis.
OBJECTIVES The aim was to assess the immunogenicity and the impact on disease activity of pneumococcal and influenza vaccines in SLE patients. METHODS We conducted a systematic literature reviewExpand
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T Follicular Helper Cells in Autoimmune Disorders
T follicular helper (Tfh) cells are a distinct subset of CD4+ T lymphocytes, specialized in B cell help and in regulation of antibody responses. They are required for the generation of germinalExpand
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The epigenetic landscape of age-related diseases: the geroscience perspective
In this review, we summarize current knowledge regarding the epigenetics of age-related diseases, focusing on those studies that have described DNA methylation landscape in cardio-vascular diseases,Expand
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Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review
BackgroundThe aim of this study was to identify the most reliable biomarkers in the literature that could be used as flare predictors in systemic lupus erythematosus (SLE).MethodsA systematic reviewExpand
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Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature
The feasibility of liver transplantation from old healthy donors suggests that this organ is able to preserve its functionality during aging. To explore the biological basis of this phenomenon, weExpand
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Multimorbidity, age-related comorbidities and mortality: association of activation, senescence and inflammation markers in HIV adults
Background: The widespread introduction of combination antiretroviral therapy (cART) has increased survival of HIV-infected patients. However, the prevalence of age-related comorbidities remainsExpand
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Accelerated bio‐cognitive aging in Down syndrome: State of the art and possible deceleration strategies
Down syndrome (DS) has been proposed by George Martin as a segmental progeroid syndrome since 1978. In fact, DS persons suffer from several age‐associated disorders much earlier than euploid persons.Expand
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The epigenetics of inflammaging: The contribution of age-related heterochromatin loss and locus-specific remodelling and the modulation by environmental stimuli.
A growing amount of evidences indicates that inflammaging - the chronic, low grade inflammation state characteristic of the elderly - is the result of genetic as well as environmental or stochasticExpand
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The Impact of Caloric Restriction on the Epigenetic Signatures of Aging
Aging is characterized by an extensive remodeling of epigenetic patterns, which has been implicated in the physiopathology of age-related diseases. Nutrition plays a significant role in modulatingExpand
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T follicular helper cells, interleukin‐21 and systemic lupus erythematosus
Abstract SLE is a chronic systemic autoimmune disease characterized by a breakdown of tolerance to nuclear antigens and generation of high‐affinity pathogenic autoantibodies. These autoantibodiesExpand
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