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Menthol: a natural analgesic compound
TLDR
Results indicate that (-)-menthol is endowed with analgesic properties mediated through a selective activation of kappa-opioid receptors. Expand
Satiety factor oleoylethanolamide recruits the brain histaminergic system to inhibit food intake
TLDR
The results demonstrate that OEA requires the integrity of the brain histamine system to fully exert its hypophagic effect and that the oxytocin neuron-rich nuclei are the likely hypothalamic area where brain Histamine influences the central effects of OEA. Expand
Signaling pathway of morphine induced acute thermal hyperalgesia in mice
TLDR
This study demonstrates the presence of a nociceptive PLCβ3/PKCγ/NMDA pathway stimulated by low concentrations of morphine, through μOR1 receptor, in mouse brain, which appears to play an opposing role in morphine analgesia. Expand
Alpha-2 agonist-induced memory impairment is mediated by the alpha-2A-adrenoceptor subtype
TLDR
Results indicate that clonidine and guanabenz impaired memory processes in a mouse passive avoidance paradigm through the selective activation of the alpha2A-adrenoceptor subtype. Expand
Different involvement of type 1, 2, and 3 ryanodine receptors in memory processes.
TLDR
The findings showed the involvement of type 2 and type 3 RyR in the modulation of memory functions identifying these cerebral RyR isoforms as critical targets underlying memory processes. Expand
Effect of potassium channel modulators in mouse forced swimming test
TLDR
Results suggest that modulation of potassium channels plays an important role in the regulation of immobility time in the mouse forced swimming test, and that potassium channels modulators and the mKv1.c.1 aODN did not impair motor coordination, as revealed by the rota rod test. Expand
Local anaesthetic activity of the essential oil of Lavandula angustifolia.
TLDR
In the rabbit conjunctival reflex test treatment with a solution of essential oil of L. angustifolia, as well as linalyl acetate and linalol allow a dose-dependent increase in the number of stimuli necessary to provoke the reflex, thus confirming in vivo the local anaesthetic activity observed in vitro. Expand
Role of 5-HT4 receptors in the mouse passive avoidance test.
TLDR
The results suggest that the modulation of 5-HT4 receptors plays an important role in the regulation of memory processes and the 5- HT4 receptor antagonists may represent pharmacological tools for investigation of new potential antiamnesic drugs. Expand
Pleiotropic effect of histamine H4 receptor modulation in the central nervous system
TLDR
Results show the antinociceptive, antiamnesic, anxiolytic and anorexant effects induced by neuronal H4R agonism, suggesting that H4 modulators may have broader utility further the control of inflammatory and immune processes. Expand
Neurotransmitter role of endogenous morphine in CNS.
TLDR
Findings indicate that endogenous morphine might function as neuromodulator/neurotransmitter agent in the CNS and indirect evidence that endogenous opioids modulates thermonociception and weakens memory through mu opioid receptors supports a neurotransmitter role for this chemical messenger. Expand
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