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Control of the Na+/Ca2+ exchanger 3 promoter by cyclic adenosine monophosphate and Ca2+ in differentiating neurons
The human gene for member 3 of solute carrier family 8 (SLC8A3), encoding the Na+/Ca2+ exchanger isoform 3 (NCX3), was identified on chromosome 14q24.2. The minimal promoter region was predicted 250Expand
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Downstream Regulatory Element Antagonist Modulator Regulates Ca2+ Homeostasis and Viability in Cerebellar Neurons
The Na+/Ca2+ exchangers NCX1, NCX2, and NCX3 are vital for the control of cellular Ca2+ homeostasis. Here, we show that a doublet of downstream regulatory element sites in the promoter of the NCX3Expand
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The human SLC8A3 gene and the tissue-specific Na+/Ca2+ exchanger 3 isoforms.
We have identified the human gene for member 3 of Solute Carrier family 8 (SLC8A3) by bioinformatic analysis of human genomic sequences. The gene is located on chromosome 14q24.2, and spans a regionExpand
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Transcriptional regulation by cAMP and Ca2+ links the Na+/Ca2+ exchanger 3 to memory and sensory pathways
  • N. Gabellini
  • Biology, Medicine
  • Molecular Neurobiology
  • 1 August 2004
The signaling cascades triggered by neurotrophins such as BDNF and by several neurotransmitters and hormones lead to the rapid induction of gene transcription by increasing the intracellularExpand
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Trans-azetidine-2,4-dicarboxylic acid activates neuronal metabotropic receptors.
The expression of metabotropic glutamate receptors (mGluRs) in primary cultures of cerebellar granule neurones can be: (i) modulated by the degree of depolarization during the culture period,Expand
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Expression of an active Na+/Ca2+ exchanger isoform lacking the six C-terminal transmembrane segments.
The short isoform of the Na+/Ca2+ exchanger (67 kDa) that is produced by alternative splicing during the expression of the 6 kb canine exchanger cDNA in 293 cells was separately expressed in the sameExpand
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Lack of coupling of D-2 receptors to adenylate cyclase in GH-3 cells exposed to epidermal growth factor. Possible role of a differential expression of Gi protein subtypes.
Exposure of GH-3 cells to epidermal growth factor for 4 consecutive days induced the expression of both D-2(415) and D-2(444) dopamine-receptor isoforms. Epidermal growth factor also promoted aExpand
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Triggering Mechanism for DNA Electrical Conductivity: Reversible Electron Transfer between DNA and Iron Oxide Nanoparticles
A new category of iron oxide nanoparticles (surface active maghemite nanoparticles (SAMNs, γ-Fe2O3)) allows the intimate chemical and electrical contact with DNA by direct covalent binding. On theseExpand
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Electrophysiological characterization of ionic transport by the retinal exchanger expressed in human embryonic kidney cells.
The retinal Na+:Ca2+, K+exchanger cDNA was transiently expressed in human embryonic kidney (HEK 293) cells by transfection with plasmid DNA. The correct targeting of the expressed protein to theExpand
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Increased expression of LGI1 gene triggers growth inhibition and apoptosis of neuroblastoma cells
The LGI1 gene has been implicated in the malignant progression of glioblastoma and it has also been genetically linked to a form of partial epilepsy (ADLTE). In this study, we investigated theExpand
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