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Stimulation of BMP-2 Expression by Pro-Inflammatory Cytokines IL-1 and TNF-&agr; in Normal and Osteoarthritic Chondrocytes
Background: Destruction of cartilage in osteoarthritis is a direct effect of an imbalance between catabolic and anabolic activities in the tissue. While a great deal is known about catabolism, weExpand
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Common variants in DVWA on chromosome 3p24.3 are associated with susceptibility to knee osteoarthritis
Susceptibility to osteoarthritis, the most common human arthritis, is known to be influenced by genetic factors. Through a genome-wide association study using ∼100,000 SNPs, we have identified aExpand
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New Sequence Variants in HLA Class II/III Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Study
Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have beenExpand
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Influence of medial hamstring tendon harvest on knee flexor strength after anterior cruciate ligament reconstruction. A detailed evaluation with comparison of single- and double-tendon harvest.
BACKGROUND The advantages of hamstring tendon autografts for anterior cruciate ligament reconstruction are well known; however, concerns have arisen regarding the influence of hamstring tendonExpand
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Addition of an arch support improves the biomechanical effect of a laterally wedged insole.
In order to examine if the addition of an arch support could improve the biomechanical effect of the laterally wedged insole, three-dimensional gait analysis was performed on 20 healthy volunteers.Expand
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Proinflammatory role of amphiregulin, an epidermal growth factor family member whose expression is augmented in rheumatoid arthritis patients
BackgroundThe epidermal growth factor (EGF) and EGF receptor (EGFR) families play important roles in the hyperplastic growth of several tissues as well as tumor growth. Since synovial hyperplasia inExpand
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Predictors of place of death for Japanese patients with advanced‐stage malignant disease in home care settings: A nationwide survey
Although the place of death for patients with advanced malignancy is influenced by multiple factors, few studies have systematically investigated the determinants of place of death. The objective ofExpand
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Cell biology of osteoarthritis: The chondrocyte’s response to injury
Cartilage is comprised of a large amount of functional extracellular matrix that is made and maintained by a small number of chondrocytes, the sole resident cell type. Normal cartilage exists in aExpand
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Roles of chondrocytes in the pathogenesis of osteoarthritis.
Recent investigations into the striking heterogeneity of cellular reaction patterns that are characteristic for, and puzzling in, osteoarthritic cartilage degeneration addressed apoptotic cell deathExpand
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Cluster analysis of claudin‐1 and ‐4, E‐cadherin, and β‐catenin expression in colorectal cancers
Intercellular adhesion mediated by the claudin and cadherin/catenin complex is a prerequisite for epithelial integrity and differentiation, and has been suggested to be frequently disturbed inExpand
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