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Antibodies to MHC Class I Induce Autoimmunity: Role in the Pathogenesis of Chronic Rejection1
- N. Fukami, S. Ramachandran, +4 authors T. Mohanakumar
- Biology, Medicine
- The Journal of Immunology
- 1 January 2009
Alloimmunity to mismatched donor HLA-Ags and autoimmunity to self-Ags have been hypothesized to play an important role in immunopathogenesis of chronic rejection of transplanted organs. However, it… Expand
Initial experience with a tailor-made simulation and navigation program using a 3-D printer model of kidney transplantation surgery.
INTRODUCTION Three-dimensional (3-D) printing systems allow for the creation of surgical models mimicking real tissue. We developed a kidney graft and pelvic cavity replica as a patient-specific 3-D… Expand
An Obligatory Role for Lung Infiltrating B Cells in the Immunopathogenesis of Obliterative Airway Disease Induced by Antibodies to MHC Class I Molecules
- N. Fukami, S. Ramachandran, M. Takenaka, J. Weber, V. Subramanian, T. Mohanakumar
- American journal of transplantation : official…
- 1 April 2012
Using a murine model, we demonstrated that endobronchial administration of antibodies (Abs) to major histocompatibility complex (MHC) class I results in cellular infiltration, epithelial metaplasia,… Expand
Mechanism of Accommodation in a Sensitized Human Leukocyte Antigen Transgenic Murine Cardiac Transplant Model
Background. Presence of donor-specific antibodies (Abs) is detrimental to posttransplant allograft function. Some sensitized recipients have successfully undergone transplantation after pretransplant… Expand
Robot‐assisted partial nephrectomy: Superiority over laparoscopic partial nephrectomy
- R. Shiroki, N. Fukami, +4 authors H. Toyama
- International journal of urology : official…
- 1 February 2016
Nephron‐sparing surgery has been proven to positively impact the postoperative quality of life for the treatment of small renal tumors, possibly leading to functional improvements. Laparoscopic… Expand
Synergistic effect of antibodies to human leukocyte antigens and defensins in pathogenesis of bronchiolitis obliterans syndrome after human lung transplantation.
- Deepti Saini, N. Angaswamy, +7 authors T. Mohanakumar
- The Journal of heart and lung transplantation…
- 1 December 2010
BACKGROUND This study aims to determine the role of antibodies to donor-mismatched human leukocyte antigen (HLA) developed during the post-transplant period in inducing defensins and their… Expand
Serum liver‐type fatty acid‐binding protein predicts recovery of graft function after kidney transplantation from donors after cardiac death
Kidneys procured by donation after cardiac death (DCD) may increase the donor pool but are associated with high incidence of delayed graft function (DGF). Urinary liver‐type fatty acid‐binding… Expand
LMP-420, a Small Molecular Inhibitor of TNF-α, Prolongs Islet Allograft Survival by Induction of Suppressor of Cytokine Signaling-1: Synergistic Effect with Cyclosporin-A
- N. Angaswamy, N. Fukami, V. Tiriveedhi, G. Cianciolo, T. Mohanakumar
- Cell transplantation
- 1 June 2012
Inflammatory insults following islet transplantation (ITx) hinders engraftment and long-term function of the transplanted (Tx) islets. Using a murine model of ITx, we determined the role of LMP-420,… Expand
IP-10, apoptotic genes, and calcineurin subtype messenger RNA kinetics occurring in rat renal isografts from brain-dead donors.
BACKGROUND Brain death (BD) and following ischemia/reperfusion(I/R) injury has cardinal implications in kidney transplantation (Tx). We hypothesize that inflammation, apoptosis, and drug… Expand
Nutritional status in Japanese renal transplant recipients with long-term graft survival.
BACKGROUND Nutritional status affects clinical outcomes in patients with chronic renal failure. Glucose intolerance, dyslipidemia, obesity, hypertension, and a calcium-phosphorus-vitamin D imbalance… Expand