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Induction of topoisomerase II-mediated DNA cleavage by the plant naphthoquinones plumbagin and shikonin
- N. Fujii, Y. Yamashita, Y. Arima, M. Nagashima, H. Nakano
- Chemistry, BiologyAntimicrobial Agents and Chemotherapy
- 1 December 1992
Plumbagin and shikonin induced a similar DNA cleavage pattern with topoisomerase II which was different from the cleavage patterns induced with other known topoisomersase II-active drugs.
Induction of a heat-stable topoisomerase II-DNA cleavable complex by nonintercalative terpenoides, terpentecin and clerocidin.
It is shown that terpentecin and clerocidin induce topoisomerase II-mediated DNA cleavage in vitro with comparable potency to that of demethylepipodophyllotoxin ethylidene-beta-D-glucoside, suggesting that topoisomersase II is a cellular target for these drugs.
Induction of mammalian DNA topoisomerase I mediated DNA cleavage by antitumor indolocarbazole derivatives.
- Y. Yamashita, N. Fujii, C. Murakata, T. Ashizawa, M. Okabe, H. Nakano
- Chemistry, BiologyBiochemistry
- 8 December 1992
The results indicate that KT6006 and KT6528 represent a new distinct class of mammalian DNA topoisomerase I active antitumor drugs that have different properties with respect to their interaction with DNA.
Induction of mammalian DNA topoisomerase I-mediated DNA cleavage and DNA winding by bulgarein.
Inhibitors of DNA topoisomerase I and II isolated from the Coptis rhizomes.
Results indicated that protoberberine alkaloids are a chemical family which can induce cleavable complexes with topoisomerases I and II.
UCE1022, a new antitumor antibiotic with topoisomerase I mediated DNA cleavage activity, from Paecilomyces.
Recent clinical studies of camptothecin derivatives such as CPT-ll and topotecan have demonstrated that these drugs have promising potentials as new antitumor agentsX). The mechanismof action of…
The clecarmycins, new antitumor antibiotics produced by Streptomyces: fermentation, isolation and biological properties.
- N. Fujii, T. Katsuyama, E. Kobayashi, M. Hara, H. Nakano
- Chemistry, BiologyThe Journal of antibiotics
- 25 August 1995
Clecarmycins exhibited antitumor activity against leukemia P388 and sarcoma 180 in mice and showed antiproliferative activities against human HeLa S3 cells.
Induction of mammalian DNA topoisomerase I and II mediated DNA cleavage by saintopin, a new antitumor agent from fungus.
Saintopin represents a new class of antitumor agent that can induce both mammalian DNA topoisomerase I and mammalianDNA topisomerase II mediated DNA cleavage.
Induction of mammalian DNA topoisomerase II dependent DNA cleavage by antitumor antibiotic streptonigrin.
The mechanism of the topoisomerase II dependent DNA cleavage induced by streptonigrin was through the formation of a cleavage complex previously reported for topoisomersase II poisons such as 4'-(9-acridinylamino) methanesulfon-m-anisidide and epipodophyllotoxins.
Correlation between the formation of cleavable complex with topoisomerase I and growth-inhibitory activity for saintopin-type antibiotics.
- N. Fujii, Y. Yamashita, T. Mizukami, H. Nakano
- Biology, ChemistryMolecular pharmacology
- 1 February 1997
Immunoblot analysis using antibody against human topoisomerase I or II revealed that the protein linked to DNA in saintopin-type antibiotic-treated cells is most likely topoisomersase I, suggesting that saintopIn-type antibiotics interfere with topoisomes I in cells by trapping reversible topoisomease I/DNA cleavable complexes.