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Listeria monocytogenes — from saprophyte to intracellular pathogen
Listeria monocytogenes is a bacterium that lives in the soil as a saprophyte but is capable of making the transition into a pathogen following its ingestion by susceptible humans or animals. RecentExpand
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Regulation of the prfA transcriptional activator of Listeria monocytogenes: multiple promoter elements contribute to intracellular growth and cell-to-cell spread.
The prfA gene product is a transcriptional activator of Listeria monocytogenes determinants of pathogenicity. In this study, we provide direct evidence that the PrfA protein is a site-specificExpand
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Characterization of the pilF—pilD pilus‐assembly locus of Neisseria gonorrhoeae
Expression of Type IV pili by the bacterial pathogen Neisseria gonorrhoeae appears to be essential for colonization of the human host. Several N. gonorrhoeae gene products have been recentlyExpand
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γδ T cells exhibit multifunctional and protective memory in intestinal tissues.
The study of T cell memory and the target of vaccine design have focused on memory subsumed by T cells bearing the αβ T cell receptor. Alternatively, γδ T cells are thought to provide rapid immunity,Expand
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Dual promoters of the Listeria monocytogenes prfA transcriptional activator appear essential in vitro but are redundant in vivo
The PrfA transcriptional activator is an essential determinant of Listeria monocytogenes pathogenesis. prfA expression is governed by three differentially regulated promoters: prfAP1 and prfAP2,Expand
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Exploration of host–pathogen interactions using Listeria monocytogenes and Drosophila melanogaster
Summary The facultative intracellular bacterial pathogen Listeria monocytogenes is capable of replicating within a broad range of host cell types and host species. We report here the establishment ofExpand
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Characterization of flagellin expression and its role in Listeria monocytogenes infection and immunity
Flagellin is the structural component of flagella produced by many pathogenic bacteria and is a potent proinflammatory molecule that mediates these effects through Toll‐like receptor (TLR) 5. InExpand
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Isolation of Listeria monocytogenes mutants with high‐level in vitro expression of host cytosol‐induced gene products
The facultative intracellular bacterial pathogen Listeria monocytogenes dramatically increases the expression of several key virulence factors upon entry into the host cell cytosol. actA, the proteinExpand
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Identification of Novel Listeria monocytogenes Secreted Virulence Factors following Mutational Activation of the Central Virulence Regulator, PrfA
ABSTRACT Upon bacterial entry into the cytosol of infected mammalian host cells, the central virulence regulator PrfA of Listeria monocytogenes becomes activated and induces the expression ofExpand
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How the Bacterial Pathogen Listeria monocytogenes Mediates the Switch from Environmental Dr. Jekyll to Pathogenic Mr. Hyde
Listeria monocytogenes is a gram-positive bacterium with a Jekyll and Hyde personality (108): it is well adapted as a saprophyte for peaceful survival in soil and decaying vegetation (Dr. Jekyll)Expand
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