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General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal
- N. Franks
- Psychology, Medicine
- Nature Reviews Neuroscience
- 1 May 2008
The mechanisms through which general anaesthetics, an extremely diverse group of drugs, cause reversible loss of consciousness have been a long-standing mystery. Gradually, a relatively small number… Expand
Molecular and cellular mechanisms of general anaesthesia
General anaesthetics are much more selective than is usually appreciated and may act by binding to only a small number of targets in the central nervous system. At surgical concentrations their… Expand
The sedative component of anesthesia is mediated by GABAA receptors in an endogenous sleep pathway
- L. Nelson, T. Guo, J. Lu, C. Saper, N. Franks, M. Maze
- Medicine, Biology
- Nature Neuroscience
- 1 October 2002
We investigated the role of regionally discrete GABA (γ-aminobutyric acid) receptors in the sedative response to pharmacological agents that act on GABAA receptors (muscimol, propofol and… Expand
Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes.
BACKGROUND Firefly luciferase is a 62 kDa protein that catalyzes the production of light. In the presence of MgATP and molecular oxygen, the enzyme oxidizes its substrate, firefly luciferin, emitting… Expand
Temperature Dependence of the Potency of Volatile General Anesthetics: Implications for In Vitro Experiments
Background When performing experiments at room temperature with volatile general anesthetics and in vitro mammalian preparations (such as isolated neurons), the question arises as to which… Expand
The &agr;2-Adrenoceptor Agonist Dexmedetomidine Converges on an Endogenous Sleep-promoting Pathway to Exert Its Sedative Effects
Background The authors investigated whether the sedative, or hypnotic, action of the general anesthetic dexmedetomidine (a selective &agr;2-adrenoceptor agonist) activates endogenous nonrapid eye… Expand
Selective actions of volatile general anaesthetics at molecular and cellular levels.
Mechanisms of general anesthesia.
Although general anesthetics are often said to be nonspecific agents, it is likely that they act at a much more restricted set of target sites than commonly believed. The traditional view has been… Expand
Molecular targets underlying general anaesthesia
- N. Franks
- Chemistry, Medicine
- British journal of pharmacology
- 1 January 2006
The discovery of general anaesthesia, over 150 years ago, revolutionised medicine. The ability to render a patient unconscious and insensible to pain made modern surgery possible and general… Expand
Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia
Perinatal asphyxia can result in neuronal injury with long‐term neurological and behavioral consequences. Although hypothermia may provide some modest benefit, the intervention itself can produce… Expand