Genetic studies of body mass index yield new insights for obesity biology
- A. Locke, Bratati Kahali, E. Speliotes
- BiologyNature
- 11 February 2015
A genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals provide strong support for a role of the central nervous system in obesity susceptibility.
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
- J. Dupuis, C. Langenberg, I. Barroso
- Medicine, BiologyNature Genetics
- 17 January 2010
It is demonstrated that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes.
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
- A. Morris, B. Voight, M. McCarthy
- BiologyNature Genetics
- 26 July 2012
A meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, finds a long tail of additional common variant loci explaining much of the variation in susceptibility to type 2 diabetes.
Defining the role of common variation in the genomic and biological architecture of adult human height
- A. Wood, T. Esko, T. Frayling
- BiologyNature Genetics
- 8 September 2014
The results indicate a genetic architecture for human height that is characterized by a very large but finite number of causal variants, including mTOR, osteoglycin and binding of hyaluronic acid.
Common genetic determinants of vitamin D insufficiency: a genome-wide association study
- Thomas J. Wang, Feng Zhang, T. Spector
- Medicine, BiologyThe Lancet
- 17 July 2010
New genetic loci link adipose and insulin biology to body fat distribution
- D. Shungin, T. Winkler, K. Mohlke
- BiologyNature
- 16 December 2014
A genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis.
- R. Chowdhury, S. Warnakula, E. Di Angelantonio
- MedicineAnnals of Internal Medicine
- 18 March 2014
Current evidence does not clearly support cardiovascular guidelines that encourage high consumption of polyunsaturated fatty acids and low consumption of total saturated fats.
Genome-wide association study identifies eight loci associated with blood pressure
- C. Newton-Cheh, T. Johnson, P. Munroe
- Biology, MedicineNature Genetics
- 1 June 2009
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We…
Epidemiology of diabetes
- N. Forouhi, N. Wareham
- MedicineMedicine
- 1 December 2014
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
- R. Scott, V. Lagou, I. Barroso
- BiologyNature Genetics
- 9 August 2012
Gene-based analyses identified further biologically plausible loci, suggesting that additional loci beyond those reaching genome-wide significance are likely to represent real associations and further functional analysis of these newly discovered loci will further improve the understanding of glycemic control.
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