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Toxicokinetics of p-tert-octylphenol in male Wistar rats
Abstract Only weak oestrogenic activity has been reported for p-alkylphenols compared with the physiological hormone 17β-estradiol. Despite the low potency, there is concern that due toExpand
  • 93
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Detection of 2,5-hexanedione in the urine of persons not exposed to n-hexane
  • N. Fedtke, H. Bolt
  • Chemistry, Medicine
  • International archives of occupational and…
  • 1986
SummaryThe neurotoxic n-hexane metabolite 2,5-hexanedione was detected by gas chromatography—mass spectrometry in urine samples from human subjects not exposed to n-hexane or related hydrocarbons.Expand
  • 44
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The relevance of 4,5-dihydroxy-2-hexanone in the excretion kinetics ofn-hexane metabolites in rat and man
Male Wistar rats were exposed ton-hexane concentrations between 50 and 3000 ppm for 8 h, and urinary excretion kinetics of then-hexane metabolites 1-hexanol, 2-hexanol, 3-hexanol, 2-hexanone,Expand
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Species differences in the biotransformation of ethyl chloride
Groups of male and female F-344 rats and B6C3F1 mice were exposed to 15000 ppm ethyl chloride (monochloroethane, ECL) or to air for 5 days (6 h/day). In this report, features of the P450-dependentExpand
  • 7
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Pharmacokinetics of the neurotoxin n-hexane in rat and man
The pharmacokinetics of inhaled n-hexane in rat and man were compared. In the rat metabolism was saturable. Up to 300 ppm, the metabolic rate was directly proportional to the concentration in theExpand
  • 18
  • 1
Species differences in the biotransformation of ethyl chloride
Groups of male and female F-344 rats and B6C3F1 mice were exposed to 15000 ppm ethyl chloride (monochloroethane, ECL) or to air for 5 days (6 h/day). In this report, features of GSH-dependent ECLExpand
  • 10
  • 1
Methodological investigations on the determination of n-hexane metabolites in urine
  • N. Fedtke, H. Bolt
  • Chemistry, Medicine
  • International archives of occupational and…
  • 1986
SummaryMale Wistar rats were exposed to 1000 ppm n-hexane, and the excreted urinary metabolites were analyzed by capillary gas chromatography-mass spectrometry (GC-MS). 1-Hexanol, 2-hexanol,Expand
  • 43
4,5-Dihydroxy-2-hexanone: a new metabolite of N-hexane and of 2,5-hexanedione in rat urine.
  • N. Fedtke, H. Bolt
  • Chemistry, Medicine
  • Biomedical & environmental mass spectrometry
  • 1 October 1987
Male Wistar rats were exposed to 2000 ppm n-hexane or were treated with a single dose of 2,5-hexanedione (200 mg kg-1). Analysis of the urine collected after both treatments revealed the formation ofExpand
  • 18
Hydrolysis of vinyl acetate in human blood
Sir, Vinyl acetate (VAc) is metabolized mainly via hydrolysis to acetic acid and acetaldehyde, a reaction catalyzed by carboxylesterases and, to a minor extent, cholinesterases. Based on the wellExpand
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