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Efficient removal of immunoglobulin free light chains by hemodialysis for multiple myeloma: in vitro and in vivo studies.
Of patients with newly diagnosed multiple myeloma, approximately 10% have dialysis-dependent acute renal failure, with cast nephropathy, caused by monoclonal free light chains (FLC). Of these, 80 toExpand
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Treatment of acute renal failure secondary to multiple myeloma with chemotherapy and extended high cut-off hemodialysis.
BACKGROUND AND OBJECTIVES Extended hemodialysis using a high cut-off dialyzer (HCO-HD) removes large quantities of free light chains in patients with multiple myeloma. However, the clinical utilityExpand
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Extensions to a procedure for generating locally identifiable reparameterisations of unidentifiable systems.
In this paper extensions to an existing procedure for generating locally identifiable reparameterisations of unidentifiable systems are presented. These extensions further formalise the constructiveExpand
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Exploration of the intercellular heterogeneity of topotecan uptake into human breast cancer cells through compartmental modelling.
TLDR
A mathematical multi-cell model for the in vitro kinetics of the anti-cancer agent topotecan following administration into a culture medium containing a population of human breast cancer cells (MCF-7 cell line) is described. Expand
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Identifiability of uncontrolled nonlinear rational systems
TLDR
In this paper an approach for the identifiability analysis of uncontrolled rational systems of the following form will be provided. Expand
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The structural identifiability of the susceptible infected recovered model with seasonal forcing.
In this paper, it is shown that the SIR epidemic model, with the force of infection subject to seasonal variation, and a proportion of either the prevalence or the incidence measured, isExpand
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The structural identifiability and parameter estimation of a multispecies model for the transmission of mastitis in dairy cows.
A structural identifiability analysis is performed on a mathematical model for the coupled transmission of two classes of pathogen. The pathogens, classified as major and minor, are aetiologicalExpand
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Effect of Biochar Type and Size on in Vitro Rumen Fermentation of Orchard Grass Hay
Biochar, a byproduct from the biofuels industry, may be a potential feed additive in ruminant diets due to possible improvements in microbial fermentation. Therefore, the objective of this study wasExpand
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Structural identifiability analyses of candidate models for in vitro Pitavastatin hepatic uptake
TLDR
In this paper a review of the application of four different techniques (a version of the similarity transformation approach for autonomous uncontrolled systems, a non-differential input/output observable normal form approach, the characteristic set differential algebra and a recent algebraic input/ Output relationship approach) to determine the structural identifiability of certain in vitro nonlinear pharmacokinetic models is provided. Expand
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Substrate and stereochemical control of peptidoglycan crosslinking by transpeptidation by Escherichia coli PBP1B.
Penicillin binding proteins (PBPs) catalysing transpeptidation reactions that stabilize the peptidoglycan component of the bacterial cell wall are the targets of beta-lactams, the most clinicallyExpand
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