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Cytotoxic T lymphocyte antigen-4 promoter variants in breast cancer.
CTLA4 is a coinhibitory molecule expressed mainly on activated T lymphocytes. To test the putative involvement of CTLA-4 in inhibitory state of immunity to breast cancer, we genotyped 283 patientsExpand
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CTLA‐4 gene promoter and exon 1 polymorphisms in Iranian patients with gastric and colorectal cancers
Background and Aim:  Cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) is a potent immunoregulatory molecule that suppresses antitumor response by down‐regulating T‐cell activation. Effects of severalExpand
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Programmed death-1 gene polymorphism (PD-1.5 C/T) is associated with colon cancer.
Programmed death-1 (PD-1), expressed by activated T cells, is a negative regulator of T lymphocytes. The associations of the immune response-related genes with cancer have been demonstrated. In thisExpand
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Interleukin-18 promoter polymorphism is associated with lung cancer: A case-control study
Background. Interleukin-18 (IL-18) is a multifunctional cytokine that augments IFN-γ production and affects tumor immune response. In the present case-control study, we tested whether IL-18 promoterExpand
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ctla-4 gene variations may influence cervical cancer susceptibility.
BACKGROUND CTLA-4 is the key player of the immune tolerance. Particular genotypes of ctla-4 have been reported to be associated with various diseases. OBJECTIVE We aimed to evaluate the role ofExpand
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CTLA4 exon 1 and promoter polymorphisms in patients with multiple sclerosis
Objective –  The polymorphisms of exon 1 (+49 A/G) and promoter regions (−1722 T/C, −1661 A/G and −318 C/T)of cytotoxic T lymphocyte antigen 4 (CTLA4) and also haplotypes constructed from mentionedExpand
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Adipose derived stem cells (ASCs) isolated from breast cancer tissue express IL-4, IL-10 and TGF-β1 and upregulate expression of regulatory molecules on T cells: do they protect breast cancer cells
Immunomodulatory function of bone marrow derived mesenchymal stem cells in cancer has recently been investigated. But the resident mesenchymal stem cells as whole in cancer and in the breast cancerExpand
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Program death 1 (PD1) haplotyping in patients with breast carcinoma
Located on chromosome 2q37.3, the programmed death 1 (PD1) gene encodes for PD-1 (also known as CD279), a negative co-stimulator in the immune system. PD-1 renders potent inhibitory effects on T andExpand
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Umbelliprenin is cytotoxic against QU-DB large cell lung cancer cell line but anti-proliferative against A549 adenocarcinoma cells
BackgroundUmbelliprenin is a natural compound, belonging to the class of sesquiterpene coumarins. Recently, umbelliprenin has attracted the researchers' attention for its antitumor activities againstExpand
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Assessment of Different Permeabilization Methods of Minimizing Damage to the Adherent Cells for Detection of Intracellular RNA by Flow Cytometry
Background Various fixation and permeabilization techniques have been developed for detection of intracellular antigens by flow cytometry; however, there are few studies using flow cytometry toExpand
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