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A Gene from the Mesophilic Bacterium Dehalococcoides ethenogenes Encodes a Novel Mannosylglycerate Synthase
The characterized mesophilic and bifunctional mannosylglycerate synthase encoded in the genome of the bacterium Dehalococcoides ethenogenes accumulated MG, confirming that this gene product can synthesize this compatible solute and arguing for a role in osmotic adjustment in the natural host. Expand
Rubritepida flocculans gen. nov., sp. nov., a new slightly thermophilic member of the alpha-1 subclass of the Proteobacteria.
It is proposed that strain H-8T represents a new genus and a new species most closely related to Roseococcus thiosulfatophilus for which the name Rubritepida flocculans is proposed. Expand
The molecular biology of mycobacterial trehalose in the quest for advanced tuberculosis therapies.
This review deals with the latest findings on mycobacterial trehalose biosynthesis, catabolism, processing and recycling, as well with the ongoing quest for novel tre Halose-related mechanisms to be targeted by novel TB therapeutics. Expand
Specialized Roles of the Two Pathways for the Synthesis of Mannosylglycerate in Osmoadaptation and Thermoadaptation of Rhodothermus marinus*
It is concluded that the two alternative pathways for the synthesis of MG are differently regulated at the level of expression to play specific roles in the adaptation of R. marinus to two different types of aggression. Expand
Mycobacterium tuberculosis Rv2419c, the missing glucosyl-3-phosphoglycerate phosphatase for the second step in methylglucose lipopolysaccharide biosynthesis
The assignment of a new function in M. tuberculosis genome expands the understanding of this organism's genetic repertoire and of the early events in MGLP biosynthesis. Expand
Albidovulum inexpectatum gen. nov., sp. nov., a Nonphotosynthetic and Slightly Thermophilic Bacterium from a Marine Hot Spring That Is Very Closely Related to Members of the Photosynthetic Genus
It is proposed that strains FRR-10T andFRR-11 should be classified as a new species of a novel genus, Albidovulum inexpectatum, representing, at present, the most thermophilic organism within the α-3 subclass of the Proteobacteria. Expand
Meiothermus timidus sp. nov., a new slightly thermophilic yellow-pigmented species.
The name Meiothermus timidus is proposed for the new species represented by strains SPS-243(T) (=LMG 22897(T)=CIP 108604(T)), RQ-10 and RQ -12, which were recovered from hot springs in Central Portugal and the Azores. Expand
Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway
The structural characterization of the fourth enzyme of the pathway, mycobacterial maltokinase (Mak), is described, uncovering a eukaryotic-like kinase (ELK) fold, similar to methylthioribose kinases and aminoglycoside phosphotransferases, which has a novel N-terminal domain topologically resembling the cystatin family of protease inhibitors. Expand
Pathway for the Synthesis of Mannosylglycerate in the Hyperthermophilic Archaeon Pyrococcus horikoshii
The biosynthetic pathway for the synthesis of the compatible solute α-mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii is proposed based on the activities of purifiedExpand
Bifunctional CTP:Inositol-1-Phosphate Cytidylyltransferase/CDP-Inositol:Inositol-1-Phosphate Transferase, the Key Enzyme for Di-myo-Inositol-Phosphate Synthesis in Several (Hyper)thermophiles
Genome analysis showed homologous genes in all organisms known to accumulate DIP and for which genome sequences were available, and the stereochemical configuration of all the metabolites involved in DIP synthesis was established by NMR analysis. Expand