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The Genome of the African Trypanosome Trypanosoma brucei
TLDR
Comparisons of the cytoskeleton and endocytic trafficking systems of Trypanosoma brucei with those of humans and other eukaryotic organisms reveal major differences. Expand
The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas Disease
TLDR
Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention. Expand
The genome of the blood fluke Schistosoma mansoni
TLDR
Analysis of the 363 megabase nuclear genome of the blood fluke, the first sequenced flatworm, and a representative of the Lophotrochozoa offers insights into early events in the evolution of the animals, including the development of a body pattern with bilateral symmetry, and theDevelopment of tissues into organs. Expand
Comparative Genomics of Trypanosomatid Parasitic Protozoa
TLDR
No evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont is revealed, and a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters is revealed. Expand
Draft Genome of the Filarial Nematode Parasite Brugia malayi
TLDR
Comparative analysis with the free-living, model nematode Caenorhabditis elegans revealed that, despite these genes having maintained little conservation of local synteny during ∼350 million years of evolution, they largely remain in linkage on chromosomal units. Expand
The genome of the protist parasite Entamoeba histolytica
TLDR
The genome of E. histolytica is presented, which reveals a variety of metabolic adaptations shared with two other amitochondrial protist pathogens: Giardia lamblia and Trichomonas vaginalis, and provides new insights into the workings and genome evolution of a major human pathogen. Expand
The African trypanosome genome.
TLDR
Analysis of a test microarray of 400 cDNAs and small random genomic DNA fragments probed with RNAs from two developmental stages of T. brucei demonstrates that the microarray technology can be used to identify batteries of genes differentially expressed during the various life cycle stages of this parasite. Expand
A New, Expressed Multigene Family Containing a Hot Spot for Insertion of Retroelements Is Associated with Polymorphic Subtelomeric Regions of Trypanosoma brucei
TLDR
A novel gene family that forms clusters in subtelomeric regions of Trypanosoma brucei chromosomes and partially accounts for the observed clustering of retrotransposons is described and Immunofluorescence and Western blot analyses using RHS subfamily-specific immune sera show that RHS proteins are constitutively expressed and occur mainly in the nucleus. Expand
The Transcriptome of Leishmania major Developmental Stages in Their Natural Sand Fly Vector
TLDR
The first high-resolution analysis of the transcriptome dynamics of four distinct stages of Leishmania major as they develop in a natural vector, Phlebotomus duboscqi, reveals changes consistent with cell cycle arrest and the upregulation of genes associated with starvation and stress. Expand
The Alveolate Perkinsus marinus: Biological Insights from EST Gene Discovery
TLDR
The authors' transcriptome analysis of P. marinus contributes new insight into its biology and taxonomic position and provides a very informative glimpse into the expression of genes encoding functionally relevant proteins as potential targets for chemotherapy, and evidence for the presence of a relict plastid. Expand
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