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Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Amplification

Protozoan parasites of the genus Leishmania cause severe human and veterinary diseases worldwide, termed leishmaniases. A hallmark of Leishmania biology is its capacity to adapt to a variety of…
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Antimony susceptibility of Leishmania isolates collected over a 30-year period in Algeria

A trend of increasing antimony susceptibility in VL isolates during the 30-year period is reported, and the emergence of S- phenotypes correlates with the inclusion of L. killicki isolates that cause cutaneous leishmaniasis and that have emerged in Algeria during the last decade.
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Transmission Potential of Antimony-Resistant Leishmania Field Isolates

The development of antimony-resistant Leishmania infantum in natural vectors Lutzomyia longipalpis and Phlebotomus perniciosus and all three resistant strains produced fully mature late-stage infections in sand flies and the resistant phenotype was maintained after the passage through the vector.
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Synthesis of aminophenylhydroxamate and aminobenzylhydroxamate derivatives and in vitro screening for antiparasitic and histone deacetylase inhibitory activity

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Meta-analysis and discussion on challenges to translate Leishmania drug resistance phenotyping into the clinic.

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Development of a Murine Infection Model with Leishmania killicki, Responsible for Cutaneous Leishmaniosis in Algeria: Application in Pharmacology

Ear dermal injection of BALB/c mice constitutes a model to study lesions physiopathology caused by L. killicki and presents interest for in vivo screening of new compounds against this pathogen, emerging in Algeria.
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Endogenous Enzymatic Antioxidant Defense and Pathologies

The present chapter will focus on the endogenous enzymatic antioxidant defense system such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPxs), thioredoxin (Trx) and paraxonase which play an important role in homeostatic redox balance.
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Leishmanicidal and Cytotoxic Activity of Algerian Medicinal Plants on Leishmania major and Leishmania infantum

Out of the seven methanol extracts tested against promastigotes of L. major and L. infantum, three showed promising activity with potent leishmanicidal effect and acceptable selectivity indices on L.Major and Infantum.
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Leishmania antimony resistance/ susceptibility in Algerian foci

Algeria is one of the most endemic countries for cutaneous and visceral forms of leishmaniosis and has a major public health impact, according to the World Health Organization.
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Antiparasite Activity of Chitosan

Chemical deacetylation of chitin produced chitosan, a linear polysaccharide joined by β-(1,4)-linked N-acetylglucosamine units that is found especially in the structure of the shell of crustacean, cuticles of insects and cell walls of fungi and naturally it occurs only in certain fungi.
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