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Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Amplification
Protozoan parasites of the genus Leishmania cause severe human and veterinary diseases worldwide, termed leishmaniases. A hallmark of Leishmania biology is its capacity to adapt to a variety ofExpand
Antimony susceptibility of Leishmania isolates collected over a 30-year period in Algeria
A trend of increasing antimony susceptibility in VL isolates during the 30-year period is reported, and the emergence of S- phenotypes correlates with the inclusion of L. killicki isolates that cause cutaneous leishmaniasis and that have emerged in Algeria during the last decade. Expand
Transmission Potential of Antimony-Resistant Leishmania Field Isolates
The development of antimony-resistant Leishmania infantum in natural vectors Lutzomyia longipalpis and Phlebotomus perniciosus and all three resistant strains produced fully mature late-stage infections in sand flies and the resistant phenotype was maintained after the passage through the vector. Expand
Meta-analysis and discussion on challenges to translate Leishmania drug resistance phenotyping into the clinic.
This analysis paves the ways to standardize and analyze anti-leishmania susceptibility tests output in order to guide the characterization of drug-resistant isolates, the clinical decision during treatment and the search for new molecular markers. Expand
Development of a Murine Infection Model with Leishmania killicki, Responsible for Cutaneous Leishmaniosis in Algeria: Application in Pharmacology
Ear dermal injection of BALB/c mice constitutes a model to study lesions physiopathology caused by L. killicki and presents interest for in vivo screening of new compounds against this pathogen, emerging in Algeria. Expand
Synthesis of aminophenylhydroxamate and aminobenzylhydroxamate derivatives and in vitro screening for antiparasitic and histone deacetylase inhibitory activity
The antiparasitic activity of the synthetized compounds correlates well with their HDAC inhibitory activity, and the best-performing compound, named 363, is a lead compound for the future development of anti-Toxoplasma molecules. Expand
Leishmanicidal and Cytotoxic Activity of Algerian Medicinal Plants on Leishmania major and Leishmania infantum
Out of the seven methanol extracts tested against promastigotes of L. major and L. infantum, three showed promising activity with potent leishmanicidal effect and acceptable selectivity indices on L.Major and Infantum. Expand
Antiparasite Activity of Chitosan
Chitin, which after cellulose is the most abundant polysaccharide in nature, is found especially in the structure of the shell of crustacean, cuticles of insects and cell walls of fungi. Chitin is aExpand
Retrospective and ongoing researches on Leishmania antimony resistance in Algeria
The current studies engaged in Algeria on the susceptibility of Leishmania parasites will shed light not only on the occurrence of antimony resistance in this area but also on factors that are involved in the selection of antimoniate resistance in natural Leishmaniasis populations. Expand
Zoonotic cutaneous leishmaniasis and Leishmania infection among Meriones shawi population in Setif Province, Algeria
Fellahi A, Djirar N, Cherief A, Boudrissa A, Eddaikra N. 2021. Zoonotic cutaneous leishmaniasis and Leishmania infection among Meriones shawi population in Setif Province, Algeria. Biodiversitas 22:Expand