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Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis
Given the associations between chronic inflammation and epithelial cancer we studied susceptibility to skin carcinogenesis in mice deficient for the pro-inflammatory cytokine TNF-α (refs. 5,6).Expand
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Activity of human monocytes in IgE antibody‐dependent surveillance and killing of ovarian tumor cells
We have previously shown that a chimeric IgE antibody against the folic acid receptor (MOv18 IgE) inhibits tumor growth in a SCID mouse model of ovarian carcinoma. MOv18 IgE gave greater protectionExpand
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An Anti-Tumor Necrosis Factor-α Antibody Inhibits the Development of Experimental Skin Tumors
The proinflammatory cytokine tumor necrosis factor-α (TNF-α) was originally considered to have activity against malignant disease. However, recent studies suggest TNF-α may also act as an endogenousExpand
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Antitumor Activity of γ-Interferon in Ascitic and Solid Tumor Models of Human Ovarian Cancer
We have investigated the action of recombinant human gamma-interferon (rHuIFN-gamma) against human ovarian cancer xenografts growing as ascites or as bulky solid i.p. tumors in nude mice. Both formsExpand
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An anti-tumor necrosis factor-alpha antibody inhibits the development of experimental skin tumors.
The proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) was originally considered to have activity against malignant disease. However, recent studies suggest TNF-alpha may also act as anExpand
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Enhancement of metastatic potential by γ-interferon
Preincubation of murine colon 26 colon adenocarcinoma cells with {gamma}-interferon (IFN-gamma), but not {alpha}-interferon, produced a significant increase in experimental pulmonary metastases inExpand
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Interferon γ Enhancement of Metastatic Potential by Updated Version
Preincubation of murine colon 26 colon adenocarcinoma cells with 7interferon (IFN-7), but not a-interferon, produced a significant increase in experimental pulmonary métastasesin syngeneic BALB/cExpand
Ovarian Carcinoma Xenografts Tumor Burden and Prolongs Survival of Mice Bearing Human A Synthetic Matrix Metalloproteinase Inhibitor Decreases Updated
We have examined the effect of a synthetic low-molecular-weight ma trix metalloproteinase inhibitor,Expand