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Behavior, adrenocortical activity, and brain monoamines in Norway rats selected for reduced aggressiveness towards man
Wild Norway rats were selected over 20 generations for reduced aggressiveness towards man. Selection for this characteristic was accompanied by many physiological changes. Although neophobia wasExpand
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Rodent Models of Depression: Neurotrophic and Neuroinflammatory Biomarkers
Rodent models are an indispensable tool for studying etiology and progress of depression. Since interrelated systems of neurotrophic factors and cytokines comprise major regulatory mechanismsExpand
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Up-regulation of tryptophan hydroxylase-2 mRNA in the rat brain by chronic fluoxetine treatment correlates with its antidepressant effect
Tryptophan hydroxylase-2 (TPH2), the rate-limiting enzyme in 5-HT synthesis in the brain, is a candidate for participation in a mechanism mediating the antidepressant effect of selective 5-HTExpand
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Effect of repeated treatment with fluoxetine on tryptophan hydroxylase-2 gene expression in the rat brainstem
Selective serotonin (5-HT) reuptake inhibitors such as fluoxetine are widely used in the treatment of depression and anxiety; however, the mechanisms underlying their action and particularly theExpand
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proBDNF is a major product of bdnf gene expressed in the perinatal rat cortex.
In the developing brain, mature brain derived neurotrophic factor (mBDNF) and its precursor (proBDNF) exhibit prosurvival and proapoptotic functions, respectively. However, it is still unknownExpand
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Attenuation of α2A-adrenergic receptor expression in neonatal rat brain by RNA interference or antisense oligonucleotide reduced anxiety in adulthood
Brain alpha2-adrenergic receptors (alpha2-ARs) have been implicated in the regulation of anxiety, which is associated with stress. Environmental treatments during neonatal development could modulateExpand
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Resistance to the development of stress-induced behavioral despair in the forced swim test associated with elevated hippocampal Bcl-xl expression
Stress may predispose individuals toward depression through down-regulation of neurogenesis and increase in apoptosis in the brain. However, many subjects show high resistance to stress in relationExpand
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Effects of testosterone on alpha2A-adrenergic receptor expression in the rat brain
Androgens are involved in regulation of behaviour through intracellular mechanisms owing to their receptors. Involvement of intercellular messengers such as brain norepinephrine and adrenergicExpand
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Effects of Swim Stress and Fluoxetine on 5-HT1A Receptor Gene Expression and Monoamine Metabolism in the Rat Brain Regions
Changes in gene expression of the brain serotonin (5-HT) 1A receptors may be important for the development and ameliorating depression, however identification of specific stimuli that activate orExpand
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Role of the serotoninergic system in the acceleration of sexual maturation in wild Norway rats selected for reduced aggressiveness toward humans.
The role of the serotoninergic system in acceleration of the sexual development of domesticated rats (Rattus norvegicus) was assessed. The onset of age-related changes in hypothalamic serotoninExpand
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