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Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development
TLDR
It is shown by immunohistochemical analysis that TP53INP1 expression is dramatically reduced in pancreatic ductal adenocarcinoma (PDAC) and this decrease occurs early during pancreatic cancer development and a previously unknown miR-155 target presenting anti-tumoral activity is presented.
Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma
TLDR
It is reported that hypoxia increases transcription of hexosamine biosynthetic pathway genes as well as levels of O-glycosylated proteins and that O-linked N-acetylglucosaminylation of proteins is a process required for hypoxic pancreatic cancer cell survival.
TP53INP1s and Homeodomain-interacting Protein Kinase-2 (HIPK2) Are Partners in Regulating p53 Activity*
TLDR
It is demonstrated that TP53INP1s, in association with HIPK2, regulate p53 transcriptional activity on p21, mdm2, pig3, and bax promoters, and indicates that TP 53INP 1s and HIPK 2 could be partners in regulating p53 activity.
GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer
Background and aims The role of GATA factors in cancer has gained increasing attention recently, but the function of GATA6 in pancreatic ductal adenocarcinoma (PDAC) is controversial. GATA6 is
Tumor protein 53-induced nuclear protein 1 is a major mediator of p53 antioxidant function.
TLDR
The data show that TP53INP1 is a major actor of p53-driven oxidative stress response that possesses both a p 53-independent intracellular ROS regulatory function and a p52-dependent transcription regulatory function.
TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity
TLDR
The results suggest that TP53INP1s are functionally associated with p73 to regulate cell cycle progression and apoptosis, independently from p53.
Lymphatic endothelial tumors induced by intraperitoneal injection of incomplete Freund's adjuvant.
TLDR
Murine lymphangiomas represent a highly reproducible and convenient source of lymphatic endothelial cells in mice by intraperitoneal injection of incomplete Freund's adjuvant.
Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down‐regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis
TLDR
It was concluded that decrease in human Cdx1 and/or Cdx2 expression is associated with colorectal tumorigenesis.
Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes
TLDR
Patient-derived PDAC xenografts are utilized to define the epigenomic landscape of PDAC, highlighting chromatin states linked to differing disease aggressiveness and survival and offering potential new markers and therapeutic targets.
Cloning and expression of the rat vacuole membrane protein 1 (VMP1), a new gene activated in pancreas with acute pancreatitis, which promotes vacuole formation.
TLDR
A new stress-induced gene which codes for a transmembrane protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death is identified.
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