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Voxel-based lesion–symptom mapping
VLSM maps for measures of speech fluency and language comprehension in 101 left-hemisphere-damaged aphasic patients confirm the anticipated contrast between anterior and posterior areas and indicate that interacting regions facilitate Fluency and auditory comprehension, in agreement with findings from modern brain imaging.
Cognition and anatomy in three variants of primary progressive aphasia
Cognitive, genetic, and anatomical features indicate that different PPA clinical variants may correspond to different underlying pathological processes.
A new brain region for coordinating speech articulation
- N. Dronkers
- 14 November 1996
All patients with articulatory planning deficits had lesions that included a discrete region of the left precentral gyms of the insula, a cortical area beneath the frontal and temporal lobes that seems to be specialized for the motor planning of speech.
Lesion analysis of the brain areas involved in language comprehension
The Neural Architecture of the Language Comprehension Network: Converging Evidence from Lesion and Connectivity Analyses
The left MTG showed a particularly extensive structural and functional connectivity pattern which is consistent with the severity of the impairments associated with MTG lesions and which suggests a central role for this region in language comprehension.
Connected speech production in three variants of primary progressive aphasia.
It is demonstrated that a multidimensional quantification of connected speech production is necessary to characterize the differences between the speech patterns of each primary progressive aphasic variant adequately, and to reveal associations between particular aspects ofconnected speech and specific components of the neural network for speech production.
The logopenic/phonological variant of primary progressive aphasia
Investigation of phonological loop functions showed that patients were severely impaired in digit, letter, and word span tasks, and cognitive and neuroimaging data indicate that a deficit in phonological loops may be the core mechanism underlying the LPA clinical syndrome.
White matter damage in primary progressive aphasias: a diffusion tensor tractography study.
- S. Galantucci, M. Tartaglia, M. Gorno-Tempini
- Medicine, PsychologyBrain : a journal of neurology
- 1 October 2011
This study demonstrates that both careful dissection of the main language tracts and consideration of all diffusion tensor metrics are necessary to characterize the white matter changes that occur in the variants of primary progressive aphasia.
Aβ amyloid and glucose metabolism in three variants of primary progressive aphasia
The relationships between language presentation, Aβ amyloidosis, and glucose metabolism in three PPA variants using [11C]‐Pittsburgh compound B and [18F]‐labeled fluorodeoxyglucose positron emission tomography are studied.
Cognitive processing speed and the structure of white matter pathways: Convergent evidence from normal variation and lesion studies