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Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system
Evidence suggests that chronic inflammation, mitochondrial dysfunction, and oxidative stress play significant and perhaps synergistic roles in Parkinson’s disease (PD), where the primary pathology isExpand
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Green tea epigallocatechin-3-gallate (EGCG) and other flavonoids reduce Alzheimer's amyloid-induced mitochondrial dysfunction.
Amyloid-β (Aβ)-induced mitochondrial dysfunction may play a role in the onset and progression of Alzheimer's disease (AD). Therefore, therapeutics targeted to improve mitochondrial function could beExpand
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Mitochondrial amyloid-beta levels are associated with the extent of mitochondrial dysfunction in different brain regions and the degree of cognitive impairment in Alzheimer's transgenic mice.
Mitochondrial dysfunction is observed in Alzheimer's disease (AD) brain, and the amyloid-beta (Abeta) peptide is known to induce mitochondrial dysfunction. The relative degree of mitochondrialExpand
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Melatonin treatment restores mitochondrial function in Alzheimer’s mice: a mitochondrial protective role of melatonin membrane receptor signaling
Abstract:  Mitochondrial dysfunction is a hallmark of Alzheimer’s disease (AD) and is observed in mutant amyloid precursor protein (APP) transgenic mouse models of familial AD. Melatonin is a potentExpand
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Caffeine increases mitochondrial function and blocks melatonin signaling to mitochondria in Alzheimer's mice and cells
Caffeine and melatonin have been shown to protect the Swedish mutant amyloid precursor protein (APP(sw)) transgenic mouse model of Alzheimer's disease from cognitive dysfunction. But their mechanismsExpand
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Proteasome Inhibition Alters Neural Mitochondrial Homeostasis and Mitochondria Turnover*
Inhibition of proteasome activity occurs in normal aging and in a wide variety of neurodegenerative conditions including Alzheimer's disease and Parkinson's disease. Although each of these conditionsExpand
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CD45 Deficiency Drives Amyloid-β Peptide Oligomers and Neuronal Loss in Alzheimer's Disease Mice
Converging lines of evidence indicate dysregulation of the key immunoregulatory molecule CD45 (also known as leukocyte common antigen) in Alzheimer's disease (AD). We report that transgenic miceExpand
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Signaling properties of stratum oriens interneurons in the hippocampus of transgenic mice expressing EGFP in a subset of somatostatin‐containing cells
GABAergic interneurons constitute a heterogeneous group of cells that exert a powerful control on network excitability and are responsible for the oscillatory behavior crucial for informationExpand
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Gerbode ventricular septal defect diagnosed using cardiac CTA imaging
This report describes the ability of computed tomography angiography (CTA) imaging of the heart to visualize an acquired shunt between the left ventricular outflow tract (LVOT) and the right atriumExpand
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Synthetic Metalloporphyrins and Resveratrol act synergistically as enhancers of cognitive performance through reduction of deposited amyloid beta and improvement of mitochondrial function in
Objective: Aim of present study was to investigate effects of synthetic metalloporphyrins alone and porphyrins with resveratrol on mitochondrial function, cognitive performance and total andExpand
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