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Antioxidant and cytoprotective properties of high-density lipoproteins in vascular cells.
- A. Nègre-Salvayre, N. Dousset, G. Ferretti, T. Bacchetti, G. Curatola, R. Salvayre
- Chemistry, MedicineFree radical biology & medicine
- 1 October 2006
Beside their key role in the regulation of cholesterol homeostasis, HDL exhibit antioxidant and anti-inflammatory properties that participate to their general antiatherogenic effect. The purpose of…
Effect of Aluminium on Lipid Peroxidation of Human High Density Lipoproteins
- G. Ferretti, C. Marchionni, T. Bacchetti, T. Galeazzi, N. Dousset
- Chemistry, MedicineFree radical research
- 1 January 2003
The results suggest that Al 3+ induces a decrease of molecular order at the lipoprotein surface in HDL as shown by the significant increase in lipid hydroperoxides in Al-treated HDL with respect to control HDL.
Reduced Na+ -K+ -ATPase Activity and Plasma Lysophosphatidylcholine Concentrations in Diabetic Patients
Data suggest that the decrease in Na+ -K+ -ATPase activity in diabetes might be due to increased LPC concentrations, which were increased in both IDDM and NIDDM patients compared with control subjects.
Structural modifications of HDL and functional consequences.
- G. Ferretti, T. Bacchetti, A. Nègre-Salvayre, R. Salvayre, N. Dousset, G. Curatola
- Chemistry, MedicineAtherosclerosis
High density lipoproteins (HDL) are susceptible to structural modifications mediated by various mechanisms including oxidation, glycation, homocysteinylation or enzymatic degradation, which could play a role in the pathogenesis of atherosclerosis and neurodegenerative diseases such as Alzheimer's disease.
Influence of low density lipoprotein from insulin-dependent diabetic patients on platelet functions.
- R. Rabini, R. Staffolani, +5 authors L. Mazzanti
- Medicine, ChemistryThe Journal of clinical endocrinology and…
- 1 October 1999
A new mechanism with a potential role in the early development of atherosclerosis in diabetic patients is suggested, i.e. an altered interaction between circulating lipoproteins and platelets.
Increased susceptibility to lipid oxidation of low-density lipoproteins and erythrocyte membranes from diabetic patients.
- R. Rabini, P. Fumelli, +7 authors P. Valdiguie
- Chemistry, MedicineMetabolism: clinical and experimental
- 1 December 1994
Although they were apparently normolipidemic, diabetic patients showed an increased susceptibility to peroxidation in LDLs and erythrocyte membranes as compared with control subjects, which might be related to the increased incidence of atherosclerosis in diabetes.
Lipoprotein peroxidation in adult psoriatic patients.
The lipoprotein compositional changes associated with the modifications of TBARS before and after Cu2+ treatment of lipoproteins may suggest an increased risk for atherosclerosis in adult psoriatic patients.
Fluorescence analysis of lipoprotein peroxidation.
- N. Dousset, G. Ferretti, M. Taus, P. Valdiguie, G. Curatola
- Chemistry, MedicineMethods in enzymology
The abnormal receptor-mediated interactions between ox-LDL and cells are mainly related to the modifications of apoB structure, as the apoprotein plays a key role in receptor recognition.
Antioxidant properties of HDL in transgenic mice overexpressing human apolipoprotein A-II.
- E. Boisfer, D. Stengel, +4 authors A. Kalopissis
- Chemistry, MedicineJournal of lipid research
- 1 May 2002
The unchanged basal lipoprotein oxidation in transgenic mice suggests that huapoA-II-rich HDL may maintain adequate antioxidant potential, and decreases in paraoxonase and platelet-activating factor acetylhydrolase activities are best explained by lower plasma HDL levels.
Effect of aluminium ions on liposomal membranes as detected by Laurdan fluorescence.
An increase in the generalised polarisation of oxidised liposomes with respect to controls has been observed, which reveals the presence of a less polar environment surrounding the probe that changes the properties of the bilayer.