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The end of an old hypothesis: the pseudomonas signaling molecules 4-hydroxy-2-alkylquinolines derive from fatty acids, not 3-ketofatty acids.
Groups of pathogenic bacteria use diffusible signals to regulate their virulence in a concerted manner. Pseudomonas aeruginosa uses 4-hydroxy-2-alkylquinolines (HAQs), includingExpand
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Semi-rational approaches to engineering enzyme activity: combining the benefits of directed evolution and rational design.
Many research groups successfully rely on whole-gene random mutagenesis and recombination approaches for the directed evolution of enzymes. Recent advances in enzyme engineering have used aExpand
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NMR investigation of Tyr105 mutants in TEM-1 beta-lactamase: dynamics are correlated with function.
The existence of coupled residue motions on various time scales in enzymes is now well accepted, and their detailed characterization has become an essential element in understanding the role ofExpand
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Cytosolic galectin-7 impairs p53 functions and induces chemoresistance in breast cancer cells
BackgroundResistance to apoptosis induced by anti-cancer drugs is a major obstacle for the treatment of aggressive forms of breast cancer. Galectin-7 (gal-7) was recently shown to be specificallyExpand
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Short-Chain Flavor Ester Synthesis in Organic Media by an E. coli Whole-Cell Biocatalyst Expressing a Newly Characterized Heterologous Lipase
Short-chain aliphatic esters are small volatile molecules that produce fruity and pleasant aromas and flavors. Most of these esters are artificially produced or extracted from natural sources at highExpand
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Design and characterization of novel cell-penetrating peptides from pituitary adenylate cyclase-activating polypeptide.
The discovery of cell-penetrating peptide opened up new promising avenues for the non-invasive delivery of non-permeable biomolecules within the intracellular compartment. However, some setbacks suchExpand
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Structural and functional importance of local and global conformational fluctuations in the RNase A superfamily
Understanding the relationship between protein structure and flexibility is of utmost importance for deciphering the tremendous rates of reactions catalyzed by enzyme biocatalysts. It has beenExpand
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Avian lipocalin expression in chickens following Escherichia coli infection and inhibition of avian pathogenic Escherichia coli growth by Ex-FABP.
Avian pathogenic Escherichia coli (APEC) causes respiratory disease and sepsis in poultry. To persist in its host, E. coli requires essential nutrients including iron. Since iron is limited inExpand
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Kinetics of photocatalytic VOCs abatement in a standardized reactor.
A standardized micro-pilot scale continuous flow apparatus has been built up, using two types of differential photoreactors, and equipped with a refined control of the working conditions in order toExpand
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Effect of combination of essential oils and bacteriocins on the efficacy of gamma radiation against Salmonella Typhimurium and Listeria monocytogenes
Abstract Purpose: Using essential oils (EO) alone or combined EO with nisin to enhance the lethality of Salmonella Typhimurium and Listeria monocytogenes to γ-irradiation treatment. Materials andExpand
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