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A Vitamin D Receptor/SMAD Genomic Circuit Gates Hepatic Fibrotic Response
Liver fibrosis is a reversible wound-healing response involving TGFβ1/SMAD activation of hepatic stellate cells (HSCs). It results from excessive deposition of extracellular matrix components and can… Expand
Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy
The poor clinical outcome in pancreatic ductal adenocarcinoma (PDA) is attributed to intrinsic chemoresistance and a growth-permissive tumor microenvironment. Conversion of quiescent to activated… Expand
Mediator links epigenetic silencing of neuronal gene expression with x-linked mental retardation.
Mediator occupies a central role in RNA polymerase II transcription as a sensor, integrator, and processor of regulatory signals that converge on protein-coding gene promoters. Compared to its role… Expand
Sucrose functions as a signal involved in the regulation of strawberry fruit development and ripening.
Fleshy fruits are classically divided into climacteric and nonclimacteric types. It has long been thought that the ripening of climacteric and nonclimacteric fruits is regulated by ethylene and… Expand
BRD4 is a novel therapeutic target for liver fibrosis
- N. Ding, Nasun Hah, +7 authors R. Evans
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 7 December 2015
Significance Liver fibrosis and cirrhosis are chronic liver diseases, resulting in life-threatening conditions with no FDA-approved therapy. Here, we identify bromodomain-containing protein 4 (BRD4)… Expand
MED19 and MED26 Are Synergistic Functional Targets of the RE1 Silencing Transcription Factor in Epigenetic Silencing of Neuronal Gene Expression*
- N. Ding, Chieri Tomomori-Sato, S. Sato, R. Conaway, J. Conaway, T. G. Boyer
- Biology, Medicine
- Journal of Biological Chemistry
- 30 January 2009
A key hub for the orchestration of epigenetic modifications necessary to restrict neuronal gene expression to the nervous system is the RE1 silencing transcription factor (REST; also known as neuron… Expand
Adiponectin Protects Rat Myocardium against Chronic Intermittent Hypoxia-Induced Injury via Inhibition of Endoplasmic Reticulum Stress
Obstructive sleep apnea syndrome (OSAS) is associated with many cardiovascular disorders such as heart failure, hypertension, atherosclerosis, and arrhythmia and so on. Of the many associated… Expand
A safe and potent anti-CD19 CAR T cell therapy
Anti-CD19 chimeric antigen receptor (CAR) T cell therapies can cause severe cytokine-release syndrome (CRS) and neurotoxicity, impeding their therapeutic application. Here we generated a new… Expand
Mechanical Ventilation Enhances HMGB1 Expression in an LPS-Induced Lung Injury Model
Background Mechanical ventilation (MV) can augment inflammatory response in lipopolysaccharide (LPS) challenged lungs. High mobility group box 1 protein (HMGB1) is a pro-inflammatory mediator in… Expand
Incidence and outcome of adult in-hospital cardiac arrest in Beijing, China.
OBJECTIVE To assess the incidence and outcome of in-hospital cardiac arrests (IHCAs) in Beijing, China. METHODS The incidence and outcome of IHCAs over a 12-month period were evaluated in this… Expand