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Genetic loci influencing kidney function and chronic kidney disease
TLDR
Using genome-wide association, common variants at 2p12–p13, 6q26, 17q23 and 19q13 associated with serum creatinine associated with chronic kidney disease are identified. Expand
A multicenter study on the effects of lanthanum carbonate (Fosrenol) and calcium carbonate on renal bone disease in dialysis patients.
TLDR
LC is a poorly absorbed, well-tolerated, and efficient phosphate binder in dialysis patients, who show almost no evolution toward low bone turnover over one year (unlike CC-treated patients), nor do they experience any aluminum-like effects on bone. Expand
Circulating nonphosphorylated carboxylated matrix gla protein predicts survival in ESRD.
TLDR
Lower levels of circulating dp-cMGP may serve as a predictor of mortality in dialysis patients, and whether vitamin K supplementation improves outcomes requires further study. Expand
Belgrade virus: a new hantavirus causing severe hemorrhagic fever with renal syndrome in Yugoslavia.
TLDR
Data indicate that two distinct hantaviruses, one of which constitutes a new serotype, cause clinically severe HFRS in Yugoslavia. Expand
Assisted peritoneal dialysis as a method of choice for elderly with end-stage renal disease
TLDR
As expected, the elderly have a higher mortality rate than younger patients treated by assisted PD, but technique failure rate, overall peritonitis rate, and most quality-of-life (QoL) measures are comparable with those of younger patients. Expand
Glutathione S-transferase A1, M1, P1 and T1 null or low-activity genotypes are associated with enhanced oxidative damage among haemodialysis patients.
TLDR
According to the GST genotype, ESRD patients may be stratified in terms of the level of oxidative and carbonyl stress that might influence cardiovascular prognosis, but could also improve efforts towards individualization of antioxidant treatment. Expand
Uremic pruritus and skin mast cells.
TLDR
Favorable therapeutic effects in patients with pruritus were achieved either with iron supplementation in those with hypoferremia or with antihistamines, mast cell membrane stabilizers and high-permeability membranes. Expand
Chronic Peritoneal Dialysis in the Elderly: A Review
TLDR
According to available data, peritoneal dialysis offers some advantages for elderly patients, such as hemodynamic stability, steady-state metabolic control, good control of hypertension, independence from hospital, and avoidance of repeated vascular access. Expand
Vascular access calcification predicts mortality in hemodialysis patients.
TLDR
It is suggested that detection of vascular access calcification is a cost-effective method to identify patients at increased mortality risk. Expand
Experience with a Large Dose (500 MG) of Intravenous Iron Dextran and Iron Saccharate in Peritoneal Dialysis Patients
TLDR
It is indicated that IV iron in PD patients is effective in restoring iron stores and in decreasing EPO requirements and as much caution be exercised with iron saccharate as with iron dextran. Expand
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